摘要
目的研究不同强化方案治疗初诊2型糖尿病的临床效果。方法选取我院2013年9月至2015年9月期间收治的168例初诊2型糖尿病患者,根据使用的药物不同分为A、B、C三组,每组56例。A组给予单纯的胰岛素治疗,B组给予二甲双胍+甘精胰岛素治疗,C组给予二甲双胍+格列美脲治疗。观察比较三组患者治疗前后空腹血糖(FBG)、餐后2 h血糖(2hPBG)、糖化血红蛋白(HbA1c)等的变化情况。结果三组患者治疗后,FBG、2hPBG、HbA1c水平均较治疗前下降,且A组的下降水平更为显著(P<0.05)。A组和B组治疗血糖达标的时间明显低于C组,差异具有统计学意义(P<0.05)。结论三种强化方案治疗初诊2型糖尿病,均可有效改善患者的糖代谢、细胞功能及胰岛素的敏感性,而糖代谢异常的患者单纯采用胰岛素治疗效果更显著。
Objective To study the clinical efficacy of different reinforcement schemes in treatment of newly diagnosed type 2 diabetes mellitus. Methods 168 cases of patients with newly diagnosed type 2 diabetes mellitus treated in our hospital from September 2013 to September 2015 were selected and divided into group A, group B and group C according to different medication, with 56 cases in each group. Group A was only given insulin therapy, group B was given metformin ＋ insulin glargine therapy, group C was given metformin ＋ glimepiride therapy. The changes of fasting blood-glucose （FBG）, 2 h postprandial blood glucose （2hPBG） and glycosylated hemoglobin （HbAlc） in three groups before and after treatment were observed and compared. Results After treatment, the levels of FBG, 2hPBG and HbAlc of three groups decreased significantly, and the decrease degree of group A was obvious, P 〈0.05. The time of blood glucose returning to normal level of group A and group B was significantly lower than that of group C, with statistical difference （P 〈0.05）. Conclusions Three kinds of reinforcement schemes in treatment of newly diagnosed type 2 diabetes mellitus can effectively improve the patient＇s glucose metabolism, cell fimction and insulin sensitivity. Single insulin treatment has significant treatment effect in patients with abnormal glucose metabolism.
出处
《临床医学工程》
2016年第4期439-440,共2页
Clinical Medicine & Engineering
关键词
初诊2型糖尿病
治疗方案
糖代谢
Β细胞功能
临床效果
Newly diagnosed type 2 diabetes mellitus
Treatment scheme
Glucose metabolism
β cell fimction
Clinical efficacy
