摘要
目的:探讨慢性心力衰竭患者血清可溶性血清基质裂解素(s ST2)水平与心力衰竭的相关性和临床意义。方法:选择33例慢性心力衰竭患者为心衰组,以同期住院的20例单纯高血压和心律失常患者为对照组。在常规检查的基础上,检测所有入选者血清s ST2和脑钠肽(BNP)水平,并行超声心动图检查;心衰组患者出院前复查血清s ST2水平。结果:心衰组患者治疗前、后血清s ST2和BNP水平均明显高于对照组(P<0.05);心衰组治疗后的s ST2水平明显低于治疗前(P<0.05)。心衰组患者血清s ST2水平与BNP水平、NYHA分级呈正相关关系(r=0.607、0.366,P<0.05),与LVEF呈负相关关系(r=-0.398,P<0.05)。结论:s ST2与慢性心衰患者心功能状态密切相关,能反映患者病情的严重程度,对心衰患者疗效和风险评估有借鉴意义。
Objective： To investigate the clinical signifi cance and correlations between serum soluble ST2（s ST2） level and chronic heart failure. Methods： 33 chronic heart failure patients were chosen as heart failure group, meanwhile 20 patients with hypertension or cardiac arrhythmias as control group. On the basis of routine examination, the serum s ST2 and brain natriuretic peptide（BNP） level of all patients were detected, and performed ultrasonic cardiogram. The serum s ST2 level of patients in heart failure group were reviewed before discharge. Results： The serum s ST2 and BNP level of patients in heart failure group before and after treatment were all obviously higher than patients in control group（P〈0.05）; Compared with that before treatment of patients in heart failure group, the serum s ST2 level after treatment declined obviously（P〈0.05）. For heart failure patients, the serum s ST2 level was positively correlated with BNP level and NYHA classifi cation（r=0.607,0.366, P〈0.05）, but negatively correlated with LVEF（r=-0.398, P〈0.05）. Conclusions： s ST2 level is closely related to cardiac function of heart failure patients; So it can refl ect the severity of the disease, and is useful for evaluation of therapeutic effects and risk assessment.
出处
《承德医学院学报》
2016年第3期196-198,共3页
Journal of Chengde Medical University
基金
河北省卫生厅科研项目指导课题(20150420)
