摘要
目的:比较右美托咪定与芬太尼类药物对清醒气管插管患者的麻醉诱导效果。方法:以陕西省第二人民医院2013年2月—2014年12月120例择期经鼻清醒气管插管麻醉患者为研究对象,按随机数字表法分为A、B组各60例,A组患者行右美托咪定麻醉,B组行芬太尼麻醉,比较2组患者不同时间点心率、血压、血氧饱和度变化情况,同时记录患者插管反应及插管知晓情况。结果:A组患者插管成功即刻的心率为(73.0±15.2)次/min,收缩压为(121.0±11.6)mm Hg(1 mm Hg=0.133 k Pa);B组为(85.6±9.2)次/min、(131.6±8.0)mm Hg,2组的差异有统计学意义(P<0.05)。A组患者出现恶心2例(3.3%)、呛咳3例(5.0%);B组恶心12例(20.0%)、呛咳15例(25.0%)、躁动9例(15.0%),2组的差异有统计学意义(P<0.05)。A组患者插管知晓率为3.3%,B组为25.0%比较,2组的差异有统计学意义(P<0.05)。结论:右美托咪定在患者清醒气管插管麻醉中具有血流动力学稳定、插管反应少、插管知晓率低等特点,值得临床推广。
OBJECTIVE： To compare the anesthesia induction effect of dexmedetomidine and fentanyl drugs on sobering patients with tracheal intubation. METHODS： 120 patients undergoing transnasal conscious endotracheal intubation anesthesia admitted into the Second People＇s Hospital of Shanxi from Feb. 2013 to Dec. 2014 were selected to be divided into group A and group B via the random number table,with 60 cases in each. Group A received dexmedetomidine anesthesia while group B were given fentanyl anesthesia. Changes of heart rate,blood pressure and oxygen saturation were compared between two group of patients at different time points,the intubation reactions and intubation awareness rate were recorded. RESULTS： The heart rate after immediate induction of anesthesia in group A was（ 73. 0 ± 15. 2） times / min,systolic blood pressure was（ 121. 0 ± 11. 6） mm Hg（ 1 mm Hg = 0. 133 k Pa）,and in group B were respectively（ 85. 6 ± 9. 2） times / min and（ 131. 6 ± 8. 0） mm Hg,with statistically significant difference（ P〈0. 05）. In group A,there were 2 case（ 3. 3%） of nausea,3 cases（ 5. 0%） of bucking,while in group B were respectively 12 cases（ 20. 0%） of of nausea,15 cases（ 25. 0%） of bucking,9 cases（ 15. 0%） of restlessness,with statistically significant difference（ P〈0. 05）. The awareness rate of intubation in group A was 3. 3%,compared with group B 25. 0%,the difference was statistically significant（ P〈0. 05）. CONCLUSIONS： Dexmedetomidine has such characteristics as stable hemodynamics,fewer intubation reactions and low intubation awareness rate in sobering patients with tracheal intubation. It is worthy of clinical application and promotion.
出处
《中国医院用药评价与分析》
2016年第3期350-352,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
右美托咪定
芬太尼
清醒气管插管
麻醉诱导
Dexmedetomidine
Fentanyl
Sobering tracheal intubation
Anesthesia induction
