摘要
目的:观察益气清肺汤联合化疗用于老年晚期非小细胞肺癌(NSCLC)患者的疗效。方法:将76例老年晚期NSCLC患者按随机数字表法分为对照组和观察组,各38例。两组患者入院后均给予水化、止吐及托烷思琼+地塞米松治疗,对照组患者第1、8天给予酒石酸长春瑞滨注射液25 mg/m2+0.9%氯化钠注射液125 ml,10 min内ivgtt;第1-3天给予顺铂注射液30 mg/m2+0.9%氯化钠注射液500 ml,3 h内ivgtt。观察组患者在对照组基础上加用益气清肺汤200 ml,每日1剂,分两次服用。两组均治疗2个月。观察两组患者临床疗效及治疗前后凝血状态、T细胞免疫功能、生存时间及生存质量。结果:观察组患者总有效率为63.1%,显著高于对照组的34.2%,差异有统计学意义(P〈0.05)。治疗前两组患者凝血状态及T细胞免疫功能比较,差异无统计学意义(P〉0.05);治疗后,观察组患者纤维蛋白原(FIB)、D-二聚体(D-D)、CD8^+水平显著降低,CD3^+、CD4^+、CD4^+/CD8^+水平显著升高,与治疗前及对照组比较,差异均有统计学意义(P〈0.05)。观察组患者中位生存时间为10.2个月,显著长于对照组的7.6个月,差异有统计学意义(P〈0.05)。治疗前,两组患者生存质量评分比较,差异无统计学意义(P〉0.05);治疗后,观察组生存质量评分显著低于对照组,差异有统计学意义(P〈0.05)。结论:益气清肺汤联合化疗能明显改善老年晚期NSCLC患者凝血状态及免疫功能,延长其生存时间,提高其生存质量。
OBJECTIVE:To observe therapeutic efficacy of Yiqi qingfei decoction combined with chemotherapy in the treatment of elder advanced non-small cell lung cancer(NSCLC). METHODS:76 elder patients with NSCLC were randomly divided into control group and observation group,with 38 cases in each group. Both groups were given hydration,antiemetics and tropisetron + dexamethasone therapy. Control group was given Vinorelbine bitartrate injection 25 mg/m2+ normal saline diluted to 125 ml,ivgtt within 10 min on the first and eighth day;given Cisplatin injection 30 mg/m2+normal saline 500 ml,ivgtt within 3 h. Observation group was addtionally given Yiqi qingfei decoction 200 ml one dose a day,at twice on the basis of control group. Both group were given 2 months of treatment. The clinical efficacy,and blood coagulation,T cell immune function,survival time and survive quality before and after treatment were observed in 2 groups. RESULTS:The total effective rate of observation group was 63.1%,which was significantly higher than that of control group(34.2%),with statistical significance(P〈0.05);there was no statistical significance in blood coagulation and T cell immune function of 2 groups before and after treatment(P〉0.05);after treatment,fibrinogen(FIB),D-dimer(D-D)and CD8^+levels of observation group were significantly reduced,while CD3^+,CD4^+and CD4^+/CD8^+were significantly increased,with statistical significance compared to before treatment and control group(P〈0.05);median survival time of observation group was 10.2 month,which was significantly longer than that of control group(7.6 month),with statistical significance(P〈0.05);before treatment,there was no statistical significance in survival quality score between 2 groups(P〉0.05);after treatment,the survive quality scores of observation group were significantly lower than that of control group,with statistical significance(P〈0.05). CONCLUSIONS:For elder patients with NSCLC,Yiqi qingfei decoctio
出处
《中国药房》
CAS
北大核心
2016年第11期1536-1539,共4页
China Pharmacy
关键词
益气清肺汤
化疗
晚期非小细胞肺癌
老年患者
Yiqi qingfei decoction
Chemotherapy
Advanced non-small cell lung cancer
Elderly patient