摘要
比较两种示踪剂(美兰、纳米炭)在早期乳腺癌前哨淋巴结活检(SLNB)中的临床应用价值。收集早期乳腺癌患者110例,随机分为纳米炭组、美兰组,术前10分钟~20分钟将两种示踪剂经乳晕周围及肿瘤周围皮下注射,美兰0.5ml^1.0ml、纳米炭0.2ml^0.5ml,首先行SLNB,然后常规行腋窝淋巴结清扫。以病理检查为标准,分别对SLNB的灵敏度、准确率、假阴性率等进行评价。结果,110例患者均找到了蓝染(美兰47例)或黑染(纳米炭63例)淋巴结,其检出率相同,均为100.00%。纳米炭组与美兰组的灵敏度分别为92.86%、100.00%,准确率为85.71%、85.10%,两组间差异无统计学意义;纳米炭组假阴性率为7.14%,美兰组假阴性率为0.00%,两组间差异无统计学意义。纳米炭及美兰在早期乳腺癌患者中行SLNB是可靠的,两种示踪剂在SLNB中的灵敏度、准确率及假阴性率无明显差异。
Comparing the clinical application value of methylene-blue and carbon nanoparticles as two tracers in the sentinel lymph node biopsy （SLNB） of early breast cancer. The authors collected 110 cases of early breast cancer patients. Randomly divided the patients into carbon nanoparticles and methylene blue group, injecting two kinds of tracer in tumor around subcutaneously or around the areola, preoperative 10～20minutes with the dose of methylene-blue 0.5ml～1ml and 0.2ml～0.5ml. First of all, the authors started with SLNB, and then axillary lymph node cleaning. Based on pathologic examination, sensitivity, accuracy, false negative rate of SLNB were evaluated. As a result, all 110 patients were found the blue dye （methylene-blue 47 cases） or black dye （carbon nanoparticles 63 cases） lymph nodes~ the detection rate is 100.00% all the same. The sensitivity of carbon nanoparticles and methylene-blue group were 92. 86%, 100. 00%, accuracy was 85.71%, 85.71 %, compared two groups, no significant statistical differences; False negative rate of carbon nanoparticles group was 7. 14%, methylene-blue group was 0. 00%, there is no statistical difference between the two groups. SLNB with carbon nanoparticles or methylene-blue in patients with early breast cancer is reliable. There is no significant statistical differences between those two kinds of tracer on sensitivity, accuracy and false negative rate in SLNB.
出处
《医学与哲学（B）》
2016年第3期26-28,85,共4页
Medicine & Philosophy(B)
关键词
纳米炭
美兰
早期乳腺癌
前哨淋巴结活检
carbon nanoparticles, methylene-blue, early breast cancer, sentinel lymph node biopsy
