摘要
目的:本实验旨在观察纳达合剂对胆汁反流性大鼠胃肠动力的调节作用。方法:利用大鼠胆汁反流性胃炎模型,将60只大鼠随机分为对照组、模型组、纳达低剂量组、纳达中剂量组、纳达高剂量组和吗丁啉组,每组10只。通过ELISA检测胆汁反流性胃炎大鼠血清胃动素(MTL)、血管活性肠肽(VIP)及胃黏膜P物质(SP)含量变化。通过比色法检测胆汁反流性胃炎大鼠胃黏膜一氧化氮(NO)含量变化。结果:纳达合剂能够显著提高胆汁反流性大鼠胃黏膜SP及血清MTL含量(P<0.05),能显著降低胆汁反流性大鼠血清VIP及NO含量(P<0.05)。结论:纳达合剂具有调节胃肠激素(SP、MTL、VIP、NO)的作用。
Objective： To observe the regulative effect of Nada Mixture on gastrointestinal motility of bile reflux gastritis（ BRG）rats. Methods： SD rats were randomly divided into control group,model group,low-dose Nada Mixture group,middle-dose Nada Mixture group,high-dose Nada Mixture group and Domperidone group. Each group has 10 rats. ELISA was used to detect SP content in gastric mucosa tissue and MTL,VIP in serum. Colorimetry was used to detect NO＇s content in gastric mucosa tissue. Results： Nada Mixture significantly increased the content of SP in gastric mucosa tissue and MTL in serum of BRG rats. And it significantly decreased the content of NO in gastric mucosa tissue and VIP in serum of BRG rats. Conclusion： Nada Mixture has the effect of regulating gastrointestinal hormones（ SP,MTL,VIP,NO）.
出处
《世界中医药》
CAS
2016年第1期117-119,122,共4页
World Chinese Medicine
基金
上海市卫生局资助项目(编号:2011ZJ006)
第二批上海市卫生系统优秀学科带头人和优秀青年人才培养计划基金资助项目(编号:沪卫计委科教[2013]9号-50)
关键词
纳达合剂
胆汁反流性胃炎
胃肠动力
Nada Mixture
Bile reflux gastritis
Gastrointestinal motility
