摘要
目的了解异基因造血干细胞移植患儿营养状况的变化。方法分别于移植前、移植后30d、60d、100d对89例异基因造血干细胞移植患儿进行身高、体质量、体质指数(BMI)、三头肌皮褶厚度(TSF)、中上臂围(MUAC)、腰围(WC)等人体学测量,同时测量脂肪组织(FM)、体脂百分比(%BF)、去脂组织(FFM)及去脂组织百分比(%FFM)等人体成分,并进行生化指标白蛋白(ALB)、前白蛋白(PreALB)测量,比较异基因造血干细胞移植患儿营养状况的改变。结果人体学测量结果显示,在移植后100d内患儿体质量、BMI、TSF均呈现先降后升趋势,在移植后30d降至最低点,然后逐渐上升(P<0.05,P<0.01),WC在移植后100d内持续升高(P<0.01);人体成分测量结果显示,%BF、FM在移植后60d内明显升高(均P<0.05),%FFM在移植后60d内显著降低(P<0.01);生化测量结果显示,ALB呈先升后降再上升的趋势,PreALB在移植后60d内显著上升(P<0.01)。结论在异基因造血干细胞移植后30d内,多数人体学及人体成分测量指标下降;而在移植后60d则存在FFM丢失和FM不断蓄积的现象。不建议将ALB和PreALB作为评价造血干细胞移植患儿营养状况的可靠指标。
Objective To understand the change of nutritional status for children receiving allogeneic hematopoietic stem cell transplantation（allo-HSCT）.Methods We measured height,weight,Body Mass Index（BMI）,Triceps Skinfold Thickness（TSF）,Mid Upper Arm Circumference（MUAC）,Waist Circumference（WC）and so on anthropometric parameters for 89 children receiving allo-HSCT at four time points：before transplantation,30,60 and 100days after transplantation,meanwhile,body compositions（Fat Mass,FM;Percent of Body Fat,%BF;Fat Free Mass,FFM;Percent of Fat Free Mass,%FFM）were measured,and biochemical indicators（albumin,ALB and prealbumin,preALB）also were tested,then we compared the change of nutritional status for the children.Results Anthropometric measurement indicated that,weight,BMI and TSF showed a similar trend of decrease at first and then increase,which reached the minimum point at 30 days,then increased gradually（P〈0.05,P〈0.01）,while WC increased gradually within 100days（P〈0.01）.Body composition measurement revealed that,%BF and FM increased significantly within the 60days（P〈0.05 for both）,while%FFM decreased significantly within the 60days（P〈0.01）.Biochemical measurement demonstrated that,ALB showed a trend of rise firstly,then decline,and rise again later,while PreALB ascended significantly within the 60days（P〈0.01）.Conclusion During the first 30 days after allo-HCT for children,most indicators of anthropometric and body composition decrease,while there is a phenomenon of FFM loss and FM accumulation within the 60 days.ALB and PreALB should not be regarded as reliable indicators of nutritional assessment for children receiving allo-HCT.
出处
《护理学杂志》
CSCD
2016年第7期78-81,共4页
Journal of Nursing Science
基金
世界健康基金会科研项目(AFINS-HOPE-2013-17)
关键词
儿童
异基因造血干细胞移植
营养状况
人体学测量
人体成分测量
生化指标测量
纵向调查
children
allogeneic hematopoietic stem cell transplantation
nutritional status
anthropometric measurement
body composition measurement
biochemical indicator measurement
longitudinal investigation
