摘要
由1,2,5,6-二丙酮甘露醇与LiAlH_4及非手性R′OH在室温形成的手性络合物对苯乙酮的不对称还原,得到光学活性的α-苯基乙醇,其旋光产率随R′OH的体积增大而提高(25%e.e),产物均为R-构型。本文初步探讨了反应机理。
Chiral complexes formed from 1,2,5,6-diisopropylidenemannitol-lithium aluminum hydride and an alcohol or phenol was used for the asymmetric re- duction of acetophenone.In all cases studied R(+) phenylmethylcarbinol was produced in excess and the optical yields increased with increasing volume of the alkyl group in the alcohol used.
出处
《北京师范大学学报（自然科学版）》
CAS
1986年第2期44-47,共4页
Journal of Beijing Normal University(Natural Science)
