摘要
用手性一元醇作辅助配体，与 １，２，５，６二丙酮甘露醇共同修饰 Ｌｉ Ａｌ Ｈ４ 对芳香酮进行对映选择还原，得到光学活性产物 ８ 个。通过与 α乙酰氧基 Ｌ丙酰氯生成非对映异构体酯，经气相 色谱分析，芳酮的光学产率为 ２３．３％ ～７１．２％ 。初步探讨了配体之间对称性匹配 的情况。
Lithium aluminum hydride modified with 1,2,5,6 diisopropylidenemannitol and other chiral alcohols was applied to reduce aromatic ketones to yield the corresponding optically active alcohols which were converted to their diastereoisomers with actyl L propionyl chloride. Gas chromatography quantitative analysis showed that the opticalyields of asymmetric reduction of aromatic ketone fell between 23.3% ~71.2%. The effect of the symmetrical matchness of ligands had also been studied.
出处
《合成化学》
CAS
CSCD
1999年第3期226-228,共3页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金
国家教委博士点基金
关键词
还原
改性
铝锂试剂
手性醇
不对称还原
芳香酮
Modification, Chiral alcohol, Asymmetric reduction, Diastereoisomer.
