摘要
血流切应力、炎症和生长因子是公认的侧枝血管生长的主要机制。动脉堵塞后侧枝血管可重塑转变为有功能的血管向阻塞血管远端供血,减少冠心病患者心肌梗死的面积。血管内皮生长因子(VEGF)介导的信号通路能促进冠脉侧支血管的形成,而Notch信号通路则能抑制侧枝血管的生长。进一步研究VEGF—Notch信号通路中主要的转换分子如Hey基因及Notch4等位基因,对侧枝血管生长理论的发展和临床应用都具有重要价值。
The flow shear stress, inflammation and growth factor are major mechanisms for the collateral vessels growth. If the coronary is blocked, collateral vessels can turn into functional vasculars, reducing myocardial infarction areas. The vascular endothelial growth factor can promote the formation of coronary collateral circulation, but Notch signaling pathway can inhibit the growth of collateral vessels. It is important to further study the main transition molecules such as hey genes and Notch4 allelic in VEGF-Notch signaling pathway.
出处
《解剖科学进展》
2016年第2期199-201,共3页
Progress of Anatomical Sciences
基金
山西省高校科技开发项目(20101101)
长治医学院科技创新团队项目(CX201415)
