摘要
血管生成素1(Ang-1)是继血管内皮生长因子(VEGF)之后,人们发现的又一重要的促血管生成因子。血管生成素家族包括Ang-l、Ang-2、Ang-3、Ang-4四种分子。其共同的特异性受体为Tie-2。目前对Ang-1/Tie2系统参与新生血管形成、促进血管成熟、抑制血管渗漏及炎症的作用研究相对深入,在创伤后修复、缺血后再通、肿瘤、糖尿病并发症及子宫内膜异位等多种病理性血管形成过程中起重要作用。
Angiopoietin-1（Ang-1） is another important promoter in angiogenesis after the vascular endothelial growth factor（VEGF）.The common specific receptor of angiopoietin family,including Ang-l,Ang-2,Ang-3 and Ang-4,is the Tie-2.It was proved that the Ang-1/Tie2 system was involved in the promotion of vascular maturation,inhibition of vascular leakage or inflammation,and played an important role in the process of pathological angiogenesis.
出处
《解剖科学进展》
CAS
2010年第1期85-88,共4页
Progress of Anatomical Sciences
基金
辽宁省科学技术计划项目临床常见
疑难疾病诊治新技术(2003225007)
