摘要
术后认知功能障碍(postoperative cognitive dysfunction,POCD)是麻醉及手术后出现的一种中枢神经系统并发症,表现为学习记忆、认知功能下降以及行为能力的退化。尤其是在老年人群中经常发生,其发生机制尚不明确,但严重影响了患者的生活质量,同时也大大增加了患者的医疗花费。而S100B蛋白是大量存在于神经组织的一种钙结合蛋白,血清和脑脊液中S100B蛋白浓度变化可以反映中枢神经系统损害的程度,是脑损伤的特异性指标,由于其在术后血清浓度的改变,常被作为老年患者POCD的评估指标之一。故对POCD和S100B蛋白相关性的研究做一综述。
POCD is described as decline in cognitive function after surgery with a predominance in the elderly patients. It is unclear whether its occurrence is result of the effects of surgery or general anesthesia,but it influences patient＇s quality of life,and increases the cost of patients. S100 B is a calcium-binding protein,which is regarded as a specific biomarker of brain injury. Due to serum concentration of S100 B increasing significantly after operation,so S100 B protein could be used to explore the anesthetic effect and acts as an indicator to evaluate POCD in the elderly. This paper reviewes above-mentioned contents as followings.
出处
《实用医药杂志》
2016年第3期276-278,共3页
Practical Journal of Medicine & Pharmacy
关键词
术后认知功能障碍
S100B蛋白
相关性
Postoperative cognitive dysfunction（POCD）
S100B protein
Relativity
