摘要
目的：观察低分子肝素联合疏血通对创伤后深静脉血栓形成（DVT）的防治作用。方法：选取我院2014年2月~2015年2月收治的创伤后DVT患者120例,依据治疗方案不同分为治疗组及对照组,各60例,治疗组采用低分子肝素钙皮下注射联合疏血通静滴治疗,对照组仅给予低分子肝素钙皮下注射治疗。对比两组治疗前后患肢肿胀程度变化及凝血指标变化,并对比临床疗效。结果：治疗组总有效率明显高于对照组（P〈0.05）;治疗组治疗后双侧肢体膝关节上、下15cm处周径平均差值均低于对照组（P〈0.05）;观察组双侧肢体周径平均差值缩小率明显高于对照组（P〈0.05）;两组治疗前凝血酶原时间（PT）、部分凝血活酶时间（APTT）、纤维蛋白原（FIB）及国际标准化比值（INR）比较无统计学差异（P〉0.05）;治疗组治疗后PT、APTT、INR明显高于对照组（P〈0.05）,FIB值明显低于对照组（P〈0.05）。结论：低分子肝素联合疏血通可有效防治创伤后DVT,无需监测出血倾向,安全有效。
Objective：To observe the effect of low molecular weight heparin in combined with Shuxuetong in preventing the post-traumatic deep venous thrombosis（DVT）.Methods：A total of 120 patients with post-traumatic DVT who were admitted in our hospital from February,2014 to February,2015 were included in the study and divided into the treatment group and the control group with 60 cases in each group according to different treatment protocols.The patients in the treatment group were given subcutaneous injection of low molecular weight heparin calcium and intravenous drip of Shuxuetong,while the patients in the control group were only given subcutaneous injection of low molecular weight heparin calcium.The changes of swelling degrees and coagulation indicators of the affected limb before and after treatment,and the clinical efficacy in the two groups were compared.Results：The total effective rate in the treatment group was significantly higher than that in the control group（P〈0.05）.The mean range of the perimeter 15 cm above and below the bilateral knee joints after treatment in the treatment group was significantly lower than that in the control group（P〈0.05）.The shrinking rate of the mean range of the perimeter of the bilateral limbs in the treatment group was significantly higher than that in the control group（P〈0.05）.The comparison of prothrombin time（PT）,activated partial thromboplastin time（APTT）,fibrinogen（FIB）,and international normalized ratio（INR）before treatment between the two groups was not statistically significant（P〉0.05）.PT,APTT,and INR after treatment in the treatment group were significantly higher than those in the control group（P〈0.05）,while FIB was significantly lower than that in the control group（P〈0.05）.Conclusions：The low molecular weight heparin in combined with Shuxuetong can effectively prevent the post-traumatic DVT,with no requirement of monitoring of the bleeding tendency and safety.
出处
《海南医学院学报》
CAS
2016年第10期1009-1011,共3页
Journal of Hainan Medical University
基金
河北省科学技术项目(15ZF0608)~~
