摘要
目的探讨首发与复发抑郁症患者的认知功能特征及两者间的差异，以及与疾病严重程度的相关性。方法招募符合DSM-1V中抑郁症诊断标准的首发抑郁症患者共31例为首发组，复发性抑郁症患者30例为复发组，健康志愿者31名为对照组，对3组进行韦氏数字广度（DS）测验、威斯康星卡片分类测验（wCST）和爱荷华赌博任务（IGT）测验，比较3组被试在各测量指标上的差异，同时用HAMD一24评估患者组的抑郁程度，并分析其与认知功能各指标的相关性。结果（1）3组患者Ds评分的差异有统计学意义（P〈0．05），其中复发组低于对照组（P〈O．05），首发组与复发组及首发组与对照组差异均无统计学意义（P〉0．05）。（2）3组患者WCST评分的差异有统计学意义，其中复发组与对照组及复发组与首发组间差异均有统计学意义（P〈0．05），首发组和对照组差异无统计学意义（P〉0．05）。（3）3组患者IGT评分的差异有统计学意义（P〈0．05），其中复发组除第二模块外，其余各项指标均高于对照组（P〈0．05），复发组的总分、第三模块和第五模块评分均高于首发组（P〈0．05）。（4）患者组（首发组＋复发组）的HAMD总分与DS评分、WCST分类数呈负相关（r=-0．373，P=0．003；r=-0．299，P=0．019），与WCST的错误应答数、持续性错误应答数、非持续错误应答数和IGT的总分、第三模块评分、第五模块评分呈正相关（r=0．265～0．461，P〈0．05），与IGT第一模块、第二模块和第四模块无相关性（P〉0．05）。结论首发抑郁症患者无明显短时记忆和执行功能损害，在情感决策方面，其倾向于低收益，低风险决策；而复发抑郁症患者的短时记忆、执行功能均有明显损害，且在情感决策上比首发患者对损失更为敏感；抑郁症患者的抑郁程度与认知损害呈正相关。疾病复发和病�
Objective To investigate the characteristic of cognitive function, its differences in pa- tients with first--episode and recurrent depression and its correlation with the severity of the disease. Methods We recruited 61 depressive patients met DSM-- IV criteria for depression from Wuxi Mental Health Center. These patients were divided into two groups： first--episode group （n = 31）, and recur- rent group （n = 30）. We also recruited 31 healthy people and assigned them into control group. All the groups were assessed with Wechsler Digit Span（DS）, Wisconsin Card Sorting Test （WCST） and Iowa Gambling Task （IGT）. Three groups were compared in the differences of each measurement, assessed the degree of depression with HAMD--24 and analyzed its correlation with the index of cognitive function. Results （1）Differences in the three groups of patients with DS score were statistically significant （P 〈 0.05）, in which the recurrent group was significantly lower than control group （P 〉 0.05）. There were no significant differences between the first--episode and recurrent group, also the first--episode and control group （P 〉0.05）. （2）Differences of WCST in the three groups were statistically significant （P 〈 0.05）, in which the differences between the recurrent and the control group, also the recurrent and fires--episode group were statistically significant （P 〈 0.05）. There was no significant difference be- tween the control group and first--episode group in WCST （P 〉 0.05）. （3）The three groups were sig- nificantly different in IGT （P 〈0.05）, in which the indicators in recurrent group were higher than the control group （P〈 0.05） except the second module. The total score, third and fifth module scores of re- current group were higher than first--episode group （P 〈0.05）. （4）The total HAMD score of depression patiens（first--episode and recurrent group） were negatively correlated with the score of the digit span and the number of classif
出处
《神经疾病与精神卫生》
2016年第1期41-45,共5页
Journal of Neuroscience and Mental Health
基金
无锡市科技创新项目（CSE31N1424）
关键词
抑郁症
复发
病程
认知功能
Depression
Recurrence
Disease duration
Cognitive function
