摘要
Rho激酶是具有GTP酶活性蛋白Rho下游的一个重要效应分子,在肌动蛋白细胞骨架重构和细胞收缩、黏附、迁移、增殖和凋亡方面起重要作用。随着Rho激酶抑制剂法舒地尔和Y27632的发现,Rho激酶的生物学功能得到广泛关注。Rho/Rho激酶信号通路参与多种肺部疾病的发生、发展,在这些疾病的动物模型中阻断该信号通路可改善疾病的病理变化和预后。本文就Rho激酶及Rho激酶抑制剂在肺部疾病中的作用研究进展作一综述。
Rho kinase is a major downstream effector of the small GTPase Rho, which plays a key role in the reconfiguration of actin cytoskeleton and is involved in a wide range of fundamental cellular functions, such as contraction, adhesion, migration, proliferation and apoptosis. Due to the discovery of effective inhibitors, such as fasudil and Y27632, the biological roles of ROCK have been extensively explored. Recently, accumulating evidence has suggested that activation of the Rho/Rho-kinase signaling pathway is substantially involved in the pathogenesis of many pulmonary diseases, while blocking of Rho/Rho-kinase signaling pathway could improve the pathological changes and prognosis of these diseases. This paper reviews the recent progress of the role of Rho kinase and its inhibitors in the pulmonary diseases.
出处
《中华实用诊断与治疗杂志》
2016年第3期225-227,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
深圳市卫生计生系统科研项目(201401087)
