摘要
目的:分析高危型人乳头瘤病毒(HR-HPV)阳性患者子宫颈脱落细胞中人乳头瘤病毒L1基因(L1)及人端粒酶RNA基因(h TERC)的表达情况。方法:自就诊于我院和温州医科大学二附院HPHPV阳性者中,选取90例宫颈组织正常者作为A组,选取90例宫颈上皮内瘤变者作为B组,选取90例宫颈癌者作为C组,对比分析三组间L1及h TERC表达情况。结果:三组间L1位点中Cp G-1、Cp G-2及Cp G-3位点的甲基化水平间存在显著差异,均以C组水平最低,以A组水平最高(P<0.05)。三组间h TERC阳性表达率存在显著差异,C组阳性表达率为83.33%最高,A组阳性表达率为26.67%最低(P<0.05)。结论:在HP-HPV阳性者中,以宫颈癌者L1位点中Cp G-1、Cp G-2及Cp G-3位点的甲基化水平及h TERC阳性表达率最高。
Objectives： To analyze the expression of human pusillanimous L1 and human agglomerate RNAgene in high- risk human pusillanimous- positive cervical shedding Cells. Methods： Among the positive HP-HPV patients in our hospital,90 cases of normal cervical tissue were selected as group A,90 cases of cervical intraepithelial neoplasia as group B and 90 cases of cervical cancer as group C. A comparative analysis between the three groups on the expression of h TERC and L1 was done. Results： The levels of lamentation at Cp G- 1,Cp G- 2 and Cp G- 3 on L1 in the three groups were significant different. Group C had the lowest level of lamentation and group A had the highest level of lamentation（ P〈0. 05）. Among the three groups,h TERC positive rate were significantly different. The positive expression rate of group C was 83. 33%（ highest）. The positive expression rate of group A was 26. 67%（ lowest）（ P〈0. 05）. Conclusion： Among HP- HPV- positive persons,levels of lamentation at Cp G- 1,Cp G- 2 and Cp G- 3 on L1 in cervical cancer patients and the positive expression rate of h TERC in cervical cancer patients are the highest.
出处
《中国性科学》
2016年第2期41-43,共3页
Chinese Journal of Human Sexuality
基金
浙江省温岭市科技计划项目(2011-1-88)
