摘要
目的:探讨B23和Ki67与宫颈癌预后的关系。方法:免疫组织化学染色检测104例宫颈癌及20例正常宫颈组织中B23和Ki67的表达水平,统计学分析宫颈癌患者生存率与B23和Ki67的表达水平的关系。结果:B23在正常宫颈组织和宫颈癌组织中的阳性率分别为30.0%和76.9%(P<0.001)。Ki67在正常宫颈组织和宫颈癌组织中阳性率分别为15.0%和44.2%(P=0.014)。单因素分析显示B23及Ki67的表达与宫颈癌的无进展生存率呈负相关。B23和Ki67的表达存在正相关关系(P<0.05)。结论:联合检测B23和Ki67可能有助于判断宫颈癌的生存率,作为临床疗效的预后指标。
Objective： To study the expressions of B 23 and Ki67 in cervical carcinoma and evaluate their roles in progonosis .Method：Tissues from 104 cervical carcinoma and 20 normal cervices were obtained with analysis of B 23 and Ki67 expressions by immunohistochemistry .Result：The positive expression rate of B23 in normal cervix and cervical carcinoma was 30.0%and 76.9%respectively （P〈0.001）, and the posi-tive expression rate of Ki67 in normal cervix and cervical carcinoma was 15.0%and 44.2%respectively （P=0.014）.The expressions of B23 and Ki67 were all negatively correlated with progressive-free survial rate of cervical carcinoma .The expression of B 23 was positively correlated with Ki 67 expression .Conclusion： The expression of Ki67 is a significant unfavorable factor of prognosis of cervical squamous cell carcinoma .Com-bined analysis of expressions of B 23 and Ki67 maybe helpful to judge prognosis of cervical carcinoma , and can be a reference factor of the clinical therapy .
出处
《河北医学》
CAS
2015年第1期3-6,共4页
Hebei Medicine
基金
广东省自然科学基金
(项目编号:s2013010015575)
广东省汕头市医疗科技计划项目
汕府科(2014)62号
