摘要
目的探讨阿司匹林、氯吡格雷联合阿托伐他汀治疗急性进展性脑梗死的有效性及安全性。方法采用数字表法将170例急性进展性脑梗死患者随机分为两组，治疗组85例，对照组85例，两组均采用阿司匹林、阿托伐他汀治疗，排除出血后治疗组加服氯吡格雷治疗，对照组继续服用阿司匹林和阿托伐他汀，两组均治疗28d。采用美国国立卫生院神经功能缺损程度评分量表（NIHSS）评分、Barthel指数（BI）对两组治疗前和治疗后7d、14d、28d进行评估，比较两组临床疗效及安全性。结果治疗组治疗后7d、14d、28dNIHSS评分分别为（12．52±3．25）分、（9．10±3．21）分、（6．87±2．85）分，对照组分别为（13．65±2．93）分、（10．73±3．41）分、（9．07±2．96）分，两组差异均有统计学意义（t=2．340、3．170、4．877，均P〈0．05）；治疗组治疗后7d、14d、28dBI指数分别为（35．26±11．18）、（53．73±13．74）、（74．61±17．35），对照组分别为（31．98±9．12）、（46．65±11．79）、（63．87±15．73），两组差异均有统计学意义（t=2．131、3．752、4．456，均P〈0．05）；治疗组治疗后7d、14d、28d总有效率分别为62．7％、79．5％、94．0％，对照组分别为51．2％、68．3％、84．1％，两组治疗后14d、28d总有效率差异均有统计学意义（x2=4．711、8．531，均P〈0．05）；两组患者均无严重不良反应。结论阿司匹林、氯吡格雷联合阿托伐他汀治疗急性进展性脑梗死有更好的临床疗效，且安全性好。
Objective To investigate the clinical advantages and safety profile of the combinational treatment of acute progressive cerebral infarction with aspirin, clopedogrel and atorvastatin. Methods 170 eases with acute progressive cerebral infarction were randomly divided into the treatment group and control group,85 patients in each group. Both two groups were initially treated with aspirin and atorvastatin. After excluding the possibility of hemorrhage, the treatment group additionally received clopedogrel ,while the control group was treated with aspirin and atorvastatin. The difference in clinical efficacy was evaluated between before treatment and 7 days, 14 days or 28 days after treatment by using the NIH Stroke Scale （ NIHSS ） and Barthel Index （ BI ）. Results The NIHSS scores of the treatment group after 7d, 14d and 28d were （ 12.52 ± 3.25 ） points, （9.10 ± 3.21 ） points and （6.87 ± 2.85 ） points, which of the control group were （ 13.65 ± 2.93 ） points, （ 10.73 ± 3.41 ） points and （9.07± 2.96） points respectively, the differences between the two groups were statistically significant（ t = 2. 340,3. 170,4. 877, all P 〈 0.05 ）. The BI scores of the treatment group after 7d, 14d and 28d were （ 35.26± 11.18）, （53.73 ± 13.74） and （74.61 ± 17.35 ）, which of the control group were （31.98± 9. 12）, （46.65 ± 11.79） and （63.87 ± 15.73） respectively, the differences between the two groups were statistically significant（ t = 2. 131,3. 752,4. 456, all P 〈 0.05 ）. The overall effective rates of the treatment group after 7d, 14d and 28d were 62.7% ,79.5% and 94.0% ,which of the control group were 51.2%, 68.3% and 84. 1% respectively. The differences of overall effective rates were statistically significant after 14d and 28d（ X2 =4. 711,8. 531, all P 〈 0.05）. Few reverse reactions were observed in both two groups. Conclusion Compared with the aspirin and atorvastatin therapy, combinational treatment of acute progressive cerebral infarction toge
出处
《中国基层医药》
CAS
2016年第3期328-332,共5页
Chinese Journal of Primary Medicine and Pharmacy
