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隐匿性乙肝献血者中TGF-β1的表达分析 被引量:5

Analysis on the levels of TGF-β1 in serum of blood donors with occult HBV infection
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摘要 目的探讨TGF-β1在隐匿性乙型肝炎病毒感染发病机制中的意义和作用。方法采用酶联免疫法(ELISA)分别测定健康对照组40例、HBV组38例以及OBI组78例的血清TGF-β1值,并分析其与ALT、乙肝血清学标志物之间的相关性。结果 OBI组血清TGF-β1水平较健康对照组升高(F=4.311,P<0.05),而HBV组较健康对照组无统计学差异(F=2.242,P>0.05);OBI组血清中TGF-β1水平在ALT≤20 U/L和20 U/L<ALT≤40 U/L 2组间无统计学差异(t=2.266,P>0.05);OBI组血清中TGF-β1与乙肝血清学标志物之间无相关性。结论血清中TGF-β1表达水平与OBI持续感染存在一定联系,其含量变化与肝脏炎症程度、乙肝血清学标志物无相关性。 Objective To explore the level of cytokines TGF-β1 and its function in serum of occult HBV infected donors in Xi'an. Methods Blood samples from 40 healthy controls,38 HBV donors and 78 OBI donors were collected. The levels of TGF-β1 were detected by ELISA. The correlation between level of TGF-β1 and ALT or the five HBV serological markers were analyzed. Results Compared with the healthy controls,OBI donors had significantly higher levels of TGF-β1( F = 4. 311,P = 0. 047). The level of TGF-β1 has no significant difference between donors with ALT≤20 U/L and 20 U/L ALT≤40 U / L( t = 2. 266,P = 0. 287). There was no correlation between the level of TGF-β1 and the five HBV markers. Conclusion There may be association between the level of TGF-β1 and the pathogenesis of OBI. The level of TGF-β1may have no correlation with the level of liver inflammation and the five HBV serological markers.
机构地区 陕西省血液中心
出处 《中国输血杂志》 CAS 北大核心 2016年第1期39-41,共3页 Chinese Journal of Blood Transfusion
基金 陕西省自然科学基金(2013JQ4041)
关键词 转化生长因子-Β1 隐匿性乙肝病毒感染 乙型肝炎病毒 TGF-β1 occult hepatitis B virus infection hepatitis B virus
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