摘要
目的探讨冠心病与甲状腺功能和相关抗体的关系。方法将经冠状动脉（简称冠脉）造影检查的82例患者中冠脉造影正常者20例作为对照组，62例存在冠脉病变者为病例组。根据冠脉受累的支数病例组又分为轻、中、重和极重4组。比较患者甲状腺功能及抗甲状腺过氧化物酶抗体（TPOAb）、抗甲状腺球蛋白抗体（TgAb）检测结果。结果病例组游离甲状腺素（FT4）的下降、TPOAb的升高与对照组比较差异有统计学意义（P〈0．05），极重度病变组血清游离三碘甲腺原氨酸（FT3）、FT4、TgAb、TPOAb水平与对照组比较差异均有统计学意义（P〈0．05），且极重度病变组的丌，下降、TPOAb升高均较其他两组比较差异有统计学意义（P〈0．05）。结论FT3、FT4下降和TPOAb、TgAb水平的升高可作为预测严重冠状动脉病变的指标。
Objetive To evaluate the relationship between the severity of coronary heart disease （CHD） and thyroid function or antibodies of thyroid. Methods We consecutively collected 82 patients with coronary angiography examination in Jinshan hospital of Fudan university. 20 patients with normal coronary artery were allocated to control group. 62 patients with coronary artery lesions by coronary angiogram were allocated to ease group. The case group was subdevided into mild, moderate, severe, and extremely severe group according to the severity of CAD. The thyroid function and antibodies against thyroid such as TPOAb/TgAb were examined. Results The down-regulated FT4 and up-regulated TPOAb levels were detected of CHD patients compared with normal controls （ P 〈 0.05 ）. The serumal titiers of FF3, FT4, TgAb and TPOAb of individuals were significantly differently expressed in extremely severe CHD patients compared with normal controls （P 〈 0.05 ）, the down-expressed FF3 and up-expressed TPOAb levels were also statistically significant in severe CHD patients than those of other groups （ P 〈 0.05 ）. Conclusion The FT3 and FF4 level is negatively but TPOAb/TgAb is positively correlated with the sever- itv of CHD.
出处
《临床内科杂志》
CAS
2016年第2期104-106,共3页
Journal of Clinical Internal Medicine
