摘要
目的 探讨不同年龄段患者冠状动脉慢血流现象(CSFP)与甲状腺功能的相关性.方法 选择2021年1月~2023年1月在我院因有胸闷、胸痛等不适症状行冠状动脉造影检查被确诊为CSFP的心内科住院患者72例为研究对象.根据患者年龄分为两组(<60岁组和≥60岁组),比较不同年龄组患者甲状腺功能及相关抗体、冠状动脉血流帧数的差异.并使用多因素Logistic回归分析CSFP形成与进展的影响因素.结果 ≥60岁组的游离甲状腺素(FT4)低于<60岁组,差异有统计学意义(P<0.05),但≥60岁组的促甲状腺激素(TSH)明显高于<60岁组,差异有统计学意义(P<0.05);≥60岁组的冠状动脉血流帧数大于<60岁组,差异有统计学意义(P<0.05);<60岁组的甲状腺球蛋白自身抗体(TGAb)及甲状腺过氧化物酶抗体(TPOAb)水平均高于≥60岁组,差异有统计学意义(P<0.05).多因素Logistic回归分析结果显示,<60岁组患者TGAb水平升高是CSFP严重程度的危险因素,≥60岁组患者TSH水平升高是CSFP严重程度的危险因素.结论 FT4、TSH、TGAb、TPOAb对不同年龄段CSFP患者冠状动脉血流缓慢程度影响不同,其中TGAb为影响<60岁组患者冠状动脉血流快慢的危险因素,而TSH为影响≥60岁组患者冠状动脉血流快慢的危险因素.
Objective To investigate the correlation between coronary slow flow phenomenon(CSFP)and thyroid function in patients of different ages.Methods 72 patients with CSFP diagnosed by coronary angiography due to chest tightness,chest pain and other discomfort symptoms in our hospital from January 2021 to January 2023 were selected as the study subjects.According to the age of the patients,they were divided into two groups(<60 years old group and≥60 years old group).The differences of thyroid function,related antibodies and coronary blood flow frames in different age groups were compared.Multivariate Logistic regression was used to analyze the influencing factors of the formation and progression of CSFP.Results Free thyroxine(FT4)in the≥60 years old group was lower than that in the<60 years old group,the difference was statistically significant(P<0.05),but thyroid-stimulating hormone(TSH)in the≥60 years old group was significantly higher than that in the<60 years old group,the difference was statistically significant(P<0.05).The number of coronary blood flow frames in the≥60 years old group was greater than that in the<60 years old group,and the difference was statistically significant(P<0.05).The levels of thyroglobulin autoantibodies(TGAb)and thyroid peroxidase antibodies(TPOAb)in the<60 years old group were higher than those in the≥60 years old group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that the increase of TGAb level in patients<60 years old was a risk factor for the severity of CSFP.The increase of TSH level in the≥60 years old group was a risk factor for the severity of CSFP.Conclusion FT4,TSH,TGAb and TPOAb have different effects on the slowness of coronary blood flow in CSFP patients of different ages.TGAb is a risk factor affecting the speed of coronary blood flow in patients<60 years old,while TSH is a risk factor affecting the speed of coronary blood flow in patients≥60 years old.
作者
吴积团
谢伟
胡根生
汤文天
WU Ji-tuan;XIE Wei;HU Gen-sheng(Department of Cardiology,Wuhu First People's Hospital,Wuhu 241000,China)
出处
《医师在线》
2024年第4期42-45,共4页
Journal of Doctors Online
