摘要
microRNA是一类含有19-22个核苷酸的非编码RNA,在转录后水平调控基因的表达,参与多种生物学过程,如细胞分化、增殖、凋亡和代谢。microRNA-182（mi R-182）属于miR-183/96/182簇（cluster）的一员,在多种细胞和组织中表达,如成骨细胞、淋巴细胞、视网膜、内耳以及脂肪组织等。研究显示miR-182在这些组织器官的正常分化、发育和功能的维持等方面均发挥了重要作用,而它的异常表达则参与了包括视网膜病变、自身免疫性疾病、肿瘤、肥胖和糖尿病等多种相关疾病的发生发展。本文对miR-182在这些疾病发生发展中的作用及其可能的机制作一综述。
microRNAs are a class of short non-coding RNAs containing about 19–22 nucleotides that regulate target gene expression through post-transcriptional repression or m RNA degradation,and involved in a variety of biological processes,such as cellular differentiation,proliferation,apoptosis and metabolism. micro RNA-182（miR-182）,belonging to mi R-183/96/182 cluster that consists of miR-182,-183,and-96,highly expresses in many cells and tissues,including osteoblasts,lymphocytes,adipocytes,retina,inner ear,etc. The recent studies of miR-182 highlighted its multiple important roles in differentiation,development,and functional maintenance in the cells and tissues. The dysregulation of miR-182 is associated with occurrence and development of many diseases,such as retinopathy,autoimmune diseases,cancers,obesity and diabetes. This review summarizes recent research progresses on the roles and mechanisms of miR-182 in cellular function and diseases.
出处
《生理学报》
CAS
CSCD
北大核心
2016年第1期107-113,共7页
Acta Physiologica Sinica
基金
supported by the National Natural Science Foundation of China(No.31471131)
International Science and Technology Cooperation Program of China(No.2014DFG32490)
the Specialized Research Fund for the Doctoral Program of Higher Education(SRFDP)of China(No.20100162120073)
