摘要
目的探讨注射区域涂抹复方利多卡因乳膏在淋巴细胞免疫治疗复发性流产患者皮内注射中的镇痛效果。方法选择110例淋巴细胞免疫治疗的复发性流产患者作为研究对象，采用非随机交叉对照设计的方法。第1组患者30例，其前2个周期采用复方利多卡因乳膏涂抹注射区域（试验组），后2两个周期采用安慰剂乳膏涂抹注射区域（对照组）；第2组患者80例，前2个周期涂抹安慰剂乳膏（对照组），后2个周期涂抹复方利多卡因乳膏（试验组）。用药1小时后对两臂行皮内注射，通过数字疼痛评分量表结合面部表情疼痛评价量表、行为学评估量表评定患者疼痛程度。分别将第1组与第2组的结果进行比较，将试验组与对照组的结果进行比较。结果试验组NRS评分均值为5．22±0.14，Wong-Banker评分均值为5．23±0．14，行为学评估量表评分均值为3．98±0．13，均低于对照组的NRS评分均值5．78±0．14．wong-Banker评分均值5．85±0．15和行为学评估量表评分均值4．78±0．15，且差异具有统计学意义（P〈0．001）。但不同治疗周期分别使用复方利多卡因乳膏或安慰剂，两阶段比较无统计学意义（P〉0．05）。结论注射区域涂抹复方利多卡因乳膏可减轻复发性流产患者在淋巴细胞免疫治疗中的疼痛，值得在临床上进行推广。
Objective To investigate the analgesic effect of compound lidocaine cream in lymphocyte immunotherapy for women with recurrent spontaneous abortion （RSA）. Methods A non-randomized controlled crossover design was adopted inclu- ding 110 patients with RSA who were receiving lymphocyte immunotherapy. There were two groups in this study. 30 patients, who were in group 1, used compound lidocaine cream in the first two cycles （test group）. And they used placebo cream in the next two cycles （ control group）. The group 2 contained 80 patients. They used placebo cream in the first two cycles （ control group） and compound lidocaine cream in the next two cycles （test group）. After 1 hour, intradermal injection was conducted. We used numerical rating scale （NRS） , Faces pain scale （Wong-Banker score） and behavioral assessment scale to assess the degree of pain. Results For test group, the mean of NRS score, Wong-Banker score and behavioral assessment scale were 5.22±0.14, 5.23±0.14 and 3.98±0.13, which were lower than the corresponding scores in the control group. For the latter, the mean of NRS score, Wong-Banker score and behavioral assessment scale were 5.78±0.14, 5.85±0.15 and 4.78±0.15. For the three assessment methods, the differences of them were statistically significant （P〈0. 00l ）. However, the effects of com- pound lidocaine cream or placebo cream in different treatment cycles showed no significant difference （ P〉0.05 ）. Conclusion For women with recurrent spontaneous abortion, compound lidocaine cream can relieve pain in the treatment of lymphocyte immu- notherapy and it is worthy to be popularized in clinical practice.
出处
《中国医院统计》
2016年第1期24-26,共3页
Chinese Journal of Hospital Statistics
基金
浙江省医药卫生科技计划平台重点资助项目(2013ZDA023)
温州市医药卫生科学研究项目(2013A06)
温州市科技局科技计划项目(Y20140040)
关键词
复方利多卡因乳膏
淋巴细胞免疫治疗
复发性流产
镇痛效果
compound lidocaine cream
lymphocyte immunotherapy
recurrent spontaneous abortion （RSA）
analgesic effect
