摘要
目的:探讨儿童过敏性紫癜急性期血浆白细胞介素9(IL-9)水平变化特点及其临床意义。方法:观察组为79例过敏性紫癜(HSP)患儿,分为无肾损害组和有肾损害两组;对照组为28例门诊健康体检儿童。ELISA测定各组儿童血浆IL-9及白细胞介素4(IL-4)水平。结果:HSP患儿血浆IL-9水平为(28.32±6.97)pg/ml,显著高于对照组(23.92±5.91)pg/ml,差异有统计学意义(t=2.98,p<0.05);HSP患儿血浆IL-4水平为(93.86±25.35)pg/ml,显著高于对照组(77.75±15.90)pg/ml,差异有统计学意义(t=3.01,p<0.05);紫癜有肾损害组及紫癜无肾损害组血清IL-4及IL-9水平较对照组明显升高,差异有统计学意义,p<0.05。紫癜有肾损害组血清IL-9水平较紫癜无肾损害组明显升高,差异有统计学意义,p<0.05。紫癜有肾损害组血清IL-4水平较紫癜无肾损害组升高不明显,差异无统计学意义,p>0.05。直线相关分析结果显示,HSP患儿血浆IL-9水平变化与IL-4水平呈显著正相关(r=0.298,p<0.05)。结论:IL-9水平的显著增高在HSP特别是紫癜性肾炎发病机制中有重要作用。
Objective： To investigate the acute anaphylactoid purpura plasma interleukin-9 （IL-9） levels characteristics and clinical significance. Methods：The study group was 79 cases of allergic purpura （HSP） in children, divided into groups, and have no kidney damage kidney damage two groups; control groupof 28 healthy children outpatients. We used ELISA to determine the level of each group of children in plasma IL-9 and interleukin 4 （IL-4）. Results： HSPchildren with plasma IL-9 level （28.32 ± 6.97） pg / ml, significantly higher （23.92 ± 5.91） pg / ml, the difference was statistically significant （t = 2.98, p 〈0.05）;HSP Children plasma IL-4 levels （93.86 ± 25.35） pg / ml, significantly higher （77.75 ± 15.90） pg / ml, the difference was statistically significant （t = 3.01, p 〈0.05）; purpura with renal impairment Purpura without renal impairment group and serum IL-4 and IL-9 levels increased significantly compared with the controlgroup, the difference was statistically significant, p 〈0.05. Purpura serum IL-9 renal impairment levels than purpura group without renal impairment weresignificantly increased, the difference was statistically significant, p 〈0.05. Purpura with renal impairment serum IL-4 levels than purpura group without renalimpairment increase was not obvious, the difference was not statistically significant, p〉 0.05. The results show a linear correlation analysis, HSP children withlevels of plasma IL-9 and IL-4 levels were significantly correlated （r = 0.298, p 〈0.05）. Conclusion： significantly higher levels of IL-9 plays an important roleespecially in HSP nephritis pathogenesis.
出处
《生物技术世界》
2016年第4期100-101,共2页
Biotech World
