摘要
目的分析新辅助化疗（NAC）对浸润性乳腺癌HER-2状态的影响效果。方法选取我院121例浸润性乳腺癌患者,分为组1（HER-2状态为阳性）19例和组2（HER-2状态为阴性）102例,均采用NAC化疗2-5个周期后,利用荧光原味杂交法检测术后HER-2状态。结果组1患者治疗后HER-2状态仍为阳性;组2 HER-2状态在NAC后有4例转阳,转阳率为3.92%,与NAC前比较差异没有统计学意义（P〉0.05）。结论 NAC对浸润性乳腺癌HER-2状态基本无影响,部分HER-2阴性者可转化为阳性,但差异没有统计学意义。
Objective Analysis the effect of neoadjuvant chemotherapy（NAC） on HER-2 status of invasive breast cancer. Methods Selected 121 cases of invasive breast cancer patients in our hospital,were divided into group 1（HER-2 state positive）（19 cases） and group 2（HER-2 state negative） 102 cases,adopted NAC after 2 to 5 cycles of chemotherapy,using the method of fluorescence natural hybridization for detection of HER-2 state. ResultsThe HER-2 status was still positive after treatment in group 1 patients. HER-2 status after NAC in 4 cases turning positive,the rate was 3.92%,and compared with before the NAC,the difference was not statistically significant（P〈0.05）. Conclusion NAC has no effect on the HER-2 status of invasive breast cancer.Though,part of patients can be converted into a positive,but the difference isnot statistically significant.
出处
《中国卫生标准管理》
2016年第2期105-106,共2页
China Health Standard Management
