摘要
目的研究精神分裂症患者未患病同胞的感觉门控脑功能活动,以探讨精神分裂症感觉门控异常遗传内表型的神经影像学表现。方法对12名首发精神分裂症患者的未患病同胞及12名年龄、性别、受教育程度相匹配的正常对照进行脑功能磁共振成像,并采用多声音刺激和单声音刺激激活脑区,以两种声音刺激下脑激活程度差值反映听觉感觉门控功能,比较两组间听觉感觉门控脑功能激活程度的差异。结果同胞组的感觉门控脑激活在右侧中扣带回(x=4,y=8,z=32)、左侧前扣带回(x=-8,y=4,z=28)大于对照组(P<0.005,体素集合>10个)。结论精神分裂症患者未患病同胞的感觉门控异常表现为扣带回异常激活,提示感觉门控异常可能是精神分裂症的一项遗传内表型标志。
Objective To investigate auditory sensory gating potential in the siblings of schizophrenic, to discover the neuroimaging features of sensory gating associated with schizophrenia as intermediate phenotypes. Methods Twelve siblings of schizophrenia patients in the first episodic, and 12 healthy controls matched in gender, age, education under- went MRI scan when performing a auditory sensory gating fMRI task （repeated clicks and single click auditory stimuli）. The measure of sensory gating was the contrast of repeated clicks minus single click. The analysis of result was imple- mented in SPM2. Results Compared with healthy controls, schizophrenia patients showed significant overactivation in the right inter cingnlate gyrus （x=4, y=8, z=32） and left anterior cingulate gyrus （x=8, y=4, z=28） during the fMRI sensory gating task. Conclusion Sensory gating is overactivated in the cingulate gyrus in siblings of schizophrenic. This pattern may be a potential endophenotype of schizophrenia.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2015年第11期641-645,共5页
Chinese Journal of Nervous and Mental Diseases
基金
广东省科技计划项目(编号:2008B030301367)
国家自然科学基金面上项目(编号:81072905)
