摘要
目的：制备交联壳聚糖／聚丙烯蹦聚氧化乙烯负载三七颗粒纳米纤维膜中药制剂，并对其体外释药特性进行研究。方法：以三七颗粒为模型中药，壳聚糖、聚丙烯酸和聚氧化乙烯为载体，利用静电纺丝和热交联技术，制备纤维膜型中药制剂；采用扫描电镜观察纤维膜的形貌，红外光谱研究纤维膜的化学结构，热失重研究样品的热稳定性，用紫外可见光谱仪表征纤维膜活性成分的释放性能。结果：交联壳聚糖／聚丙烯酸／聚氧化乙烯负载三七颗粒纳米纤维膜纤维直径为（181±71）nm。热交联使纤维膜的拉伸强度提高了35．3％，热分解温度从180℃提高到1970C．增加了纤维膜的结构稳定性。体外释药结果显示相比于普通的涂覆膜，纤维结构提高了药物活性组分的释放速率和释放总量。结论：交联壳聚糖／聚丙烯酸／聚氧化乙烯负载三七颗粒纳米纤维膜制备工艺简单，栽药均匀，具有良好的释药性能，是一种有效的中药新剂型。
Objective： To prepare the （ethylene oxide） nanofibrous membrance cross-linked chitosan/poly（ acrylic acid）/poly loaded with pseudo-ginseng and to determine its characteristics. Methods： Pseudo-ginseng entrapped in chitosan, poly （acrylic acid）, polv（ethvlene oxide） nanofibrous membrane loaded with pseudo-ginseng was prepared by electrospinning and thermal treatment method. The surface morphology of fiber membrane was observed by scanning electron microscopy and the chemical structures were characterized by infrared spectroscopy; the thermal decomposition temperature was analyzed by the thermogravimetric analysis. UV-Vis spectra were used to evaluate the in vitro release properties. Results： The average diameter of the prepared nanofibrous particles was （ 181 ± 71 ） nm. The tensile strength of fiber membrane increased by 35.3% and the decomposition temperature increased from 197 ℃ to 208 ℃ after crosslinking. Compared with casting film, the structure of fiber membrane increased the release rate and the overall amount of active components from pseudo-ginseng. Conclusion： The preparation of chitosan fiber loaded with pseudo-ginseng is simple and the dispersion of pseudo-ginseng is homogeneous. This fibrous pseudo-ginseng exhibited good release performance, providing a new Chinese medicine formulation.
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2015年第6期665-671,共7页
Journal of Zhejiang University(Medical Sciences)
基金
浙江省自然科学基金(LQ14E030003)
绍兴文理学院校级资助项目(2011LG1027)
关键词
三七/生产和制备
壳聚糖
纳米技术
药物释放系统
工艺学
制药
纤维化
Pseudo-ginseng/production ＆ preparation
Chitosan
Nanotechnology
Drug delivery systems
Technology, pharmaceutical
Fibrosis
