摘要
对海洋来源真菌Hansfordia sinuosae的化学成分进行研究,采用硅胶柱、Sephadex LH-20柱和半制备HPLC色谱分离纯化,运用1D NMR(1H NMR、13C NMR)、2D NMR(HMQC、1H-1H COSY、HMBC)及MS等现代波谱学方法并结合相关的文献,从中分离鉴定3个异香豆素类化合物,分别为:(E)-6,8-dihydroxy-3-(prop-1-en-1-yl)-1H-isochromen-1-one(1),(R)-6-hydroxymellein(2),3-methyl-6,8-dihydroxyisocoumarin(3)。其中,化合物1为新化合物,化合物3为首次在该种菌株中分离得到。
Chemical constituents of fermentation broth of marine-derived fungus Hansfordia sinuosae were studied using column chromatography, semi-preparative HPLC, ODS column chromatography and Sephadex LH-20 column chromatog- raphy, respectively. Three isocoumarin compounds were obtained. Based on 1D NMR,2D NMR, high resolution MS and IR ana/yses, their structures were elucidated as （E） -6, 8-dihydroxy-3-（ prop-l-en-1 -yl ） -1H-isochromen-l-one （ 1 ）, （R） -6-hydroxymellein （ 2 ） ,3-methyl-6,8-dihydroxyisocoumarin （3）. Compound 1 is a new compound, and compound 3 is isolated from this genus of fungus for the first time.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2016年第2期179-181,共3页
Natural Product Research and Development
