摘要
Ki-67是常用的细胞增殖标志物，尤其用于反映恶性肿瘤细胞增殖活性。近年来，大量研究对Ki-67在早期乳腺癌的价值进行了广泛的探讨，但目前对Ki-67作为常规评估乳腺癌的指标还存在强烈的争议。本文主要对Ki-67在乳腺癌预后和预测中的价值，Ki-67与其他指标联合应用的价值和Ki-67应用于临床存在的问题进行探讨和总结。
Ki-67 is a common proliferation marker, especially used to reflect the proliferation activity of malignancy cells. Recently this marker has been widely studied among early breast cancer patients, However, to date, whether include Ki67 in the list of required routine biological markers there is still a hot argument. This review mainly explores and summarizes the prognostic and predictive role of this marker in breast cancer, the clinical value of the combination of Ki-67 and other makers, and the problems lie in the application of Ki-67 in clinical practice.
出处
《国际外科学杂志》
2015年第12期851-855,共5页
International Journal of Surgery
