摘要
目的:探究黄连-肉桂药对配伍前后药性的变化。方法:将小鼠随机分为正常组、体虚(限食游泳法复制模型)组、体虚+黄连组、体虚+肉桂组、体虚+药对组、体盛(高蛋白饮食法复制模型)组、体盛+黄连组、体盛+肉桂组和体盛+药对组,每组10只。造模成功后,每组小鼠均按20 g(生药)/(kg·d)ig相应药物,正常组ig等体积生理盐水,连续7 d。记录小鼠在高温区的停留比例,检测脏器指数和生化指标钠/钾ATP酶(Na+/K+-ATPase)、钙/镁ATP酶(Ca2+/Mg2+-ATPase)、总抗氧化能力、超氧化物歧化酶活性以及血清中去甲肾上腺素、多巴胺含量等。结果:与正常组比较,体虚组小鼠在高温区停留比例升高,肝脏指数、脾脏指数、肾脏指数及生化指标活性或者含量降低(P<0.05);体盛组小鼠各项指标的变化趋势与体虚组相反,除高温区的停留比例外上述指标差异有统计学意义(P<0.05)。与体虚/体盛组比较,体虚/体盛+黄连组小鼠在高温区的停留比例、肝脏指数升高,生化指标的活性或者含量降低(P<0.05);体虚/体盛+肉桂组各指标变化趋势与体虚/体盛+黄连组相反,脾脏指数、肾脏指数升高(P<0.05);体虚/体盛+药对组小鼠在高温区的停留比例增加,各生化指标的活性或者含量降低,其中总抗氧化能力显著降低(P<0.05)。结论:肉桂之"热"不抵黄连之"寒",黄连-肉桂药对总体表现出寒凉之性。
OBJECTIVE： To explore the transform of the medicinal properties of Coptis chinensis-Cinnamomum cassia couplet medicines before and after mixing. METHODS： Mice were randomly divided into normal group, weak constitution （induced by food restriction and swimming） group, weak constitution＋C, chinensis group, weak constitution＋C, cassia group, weak constitution＋couplet medicine group, prosperous constitution （induced by high protein diet） group, prosperous eonstitution＋C, chinensis group, prosperous constitution＋C, cassia group and prosperous constitution＋couplet medicine group, with 10 mice in each group. After modeling, each group was given relevant medicine intragastrically by 20 g （crude drug）/（kg, d）, and normal group was given equivalent volume of normal saline intragastrically for consecutive 7 days. The proportion of rats remained in high-temperature areas was recorded. Organ index, biochemical index （Na^＋/K^＋-ATPase, Ca^2＋/Mg^2＋-ATPase）, total antioxidant capacity （T-AOC）, SOD activity, the serum content of noradrenalin and dopamine were detected. RESULTS： Compared with normal group, proportion of mice in high-temperature area increased in weak constitution group, while liver index, spleen index, renal index, biochemical index activity or content decreased （P〈0.05）; the change of above index in prosperous constitution group were opposite to weak con- stitution group; above index had statistical significance except for the proportion of mice in high-temperature area （P〈0.05）. Compared with weak constitution/prosperous constitution group, the proportion of mice remained in high-temperature area and liver in- dex increased in weak constitution/prosperous constitution＋C, chinensis group, while biochemical index activity or content decreased （P〈0.05） ; the change of above index in weak constitution/prosperous constitution＋C, cassia group were opposite to C. chinensis group, spleen index and renal index increased （P〈0.05） ; the proportion
出处
《中国药房》
CAS
北大核心
2016年第7期916-919,共4页
China Pharmacy
关键词
黄连
肉桂
黄连-肉桂药对
配伍
冷热板示差法
中药药性
小鼠
Coptis chinensis
Cinnamomum cassia
Coptis chinensis-Cinnamomum cassia couplet medicine
Compatibility
Cold/hot plate differentiating technology
Medicinal property
Mice
