摘要
目的比较奥美拉唑和泮托拉唑治疗消化性溃疡出血的临床疗效。方法回顾性分析60例消化性溃疡出血患者的临床资料,其中30例患者采用奥美拉唑治疗为A组,30例患者采用泮托拉唑治疗为B组,比较两组的临床疗效。结果 A组总有效率63.3%,B组总有效率96.7%。两组比较差异有统计学意义(x2=8.438,P<0.01)。A组出血停止时间(61.9±6.4)h,B组出血停止时间为(53.1±5.0)h。两组比较,差异有统计学意义(P<0.01)。A组再出血2例,B组再出血3例,两组比较,差异无统计学意义(P>0.05)。治疗后两组胃液p H值均显著上升(P<0.01),但B组上升更明显(P<0.01)。结论在常规治疗基础上,泮托拉唑治疗消化性溃疡出血临床疗效优于奥美拉唑。
Objective To discuss the clinical efficacy of omeprazole and pantoprazole in treatment of peptic ulcer bleeding. Methods Clinical data of 60 cases with peptic ulcer bleeding were respectively analyzed. Group A of 30 cases was treated with omeprazole, and group B of 30 cases was treated with pantoprazole. Clinical efficacy of two groups was compared. Results Total efficiency of group A was 63.3%, and group B was 96.7%, which showed significant difference between two groups（x2=8.438, P〈 0.01）. The bleeding stop-time of group A was（61.9±6.4）h, and group B was（53.1±5.0）h, which showed significant difference between two groups（P〈 0.01）. Rebleeding of group A was 2 cases, and group B was 1 case, there was no significant difference between two groups（P〉 0.05）. After treatment, gastrin p H of two groups were higher（P〈 0.01）. After treatment, gastrin p H of B group was higher than A group（P〈 0.01）. Conclusion Based on conventional therapy, clinical efficacy of pantoprazole in treatment of peptic ulcer bleeding is better than omeprazole.
出处
《中国医药科学》
2015年第24期57-59,共3页
China Medicine And Pharmacy
