摘要
目的:初步探索肝郁脾虚型抑郁症认知功能特征。方法:按照年龄、性别、文化程度、职业相匹配的原则,搜集30例抑郁症肝郁脾虚证患者、29例抑郁症非肝郁脾虚证患者和23名健康人,检测汉密顿抑郁量表、汉密顿焦虑量表、脑电图非线性分析关联维数(D2)、复杂度(Cx)、近似熵(Ap En)。结果:①在安静闭眼时,抑郁症患者D2、Ap En值明显低于健康人,抑郁症肝郁脾虚组与非肝郁脾虚组间无差异;②Cx值在F4-A2(右额)、C4-A2(右中央)、P3-A1(左顶)、P4-A2(右顶)、O1-A1(左枕)导联由大到小依次为健康对照组、抑郁症非肝郁脾虚组、抑郁症肝郁脾虚组;T4-A2(右中颞)、T5-A1(左后颞)导联3组Cx无差异;余导联,抑郁症组Cx较健康对照组低,组间无差异。结论:肝郁脾虚型抑郁症患者对直观视觉信息的记忆及加工较非肝郁脾虚型更困难。
Objective：To explore the liver depression and spleen deficiency cognitive functioning.Methods：According to the principle of age,gender,education level,occupation match,collecting 30 cases of liver depression and spleen deficiency depression patients,29 cases of non-liver spleen syndrome patients with depression and 23 cases of healthy people to detect the Hamilton Depression Scale（HAMD）,Hamilton anxiety Scale（HAMA）,EEG nonlinear analysis of the correlation dimension（D2）,complexity（Cx）,approximate entropy（ApEn）.Results：①When eyes closed,patients with depression D2,ApEn values significantly lower than healthy people,no difference between the liver depression and spleen deficiency depression group and non-liver spleen group;In the F4-A2（right frontal）,C4-A2（right center）,P3-A1（left top）,P4-A2（right top）,O1-A1（left occipital）lead the healthy control group,a non-liver depression spleen and liver depressionspleen depression group Cx value descending;T4-A2（right middle temporal）,T5-A1（left posterior temporal） leads three groups Cx no difference;I lead,depression Cx healthier set low,no difference between the groups.Conclusion：Liver and spleen deficiency in patients with depression to memory and processing of visual information than non-liver and spleen deficiency in patients with depression are more difficult.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2016年第2期687-691,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
河北省中医药管理局科研计划项目(No.2012078)~~
关键词
抑郁症
肝郁脾虚证
认知功能
脑电图非线性分析
Depression
Syndrome of liver depression and spleen deficiency
Cognitive function
EEG nonlinear analysis
