摘要
目的观察清营化瘀颗粒治疗急性期血栓性浅静脉炎的临床疗效。方法将80例急性期血栓性浅静脉炎患者随机分为治疗组与对照组,每组40例。治疗组予清营化瘀颗粒,对照组予通塞脉片。两组疗程均为30天,观察临床疗效,比较相关生化指标(WBC、TNF-α、CRP、IL-6)的变化情况。结果 1治疗组、对照组临床总有效率分别为92.50%和80.00%;组间临床疗效比较,治疗组优于对照组(P<0.05)。2治疗前后组内比较,两组TNF-α、CRP、IL-6水平均显著下降(P<0.05);组间治疗后比较,治疗组TNF-α、CRP、IL-6水平下降程度较对照组更加显著(P<0.05)。结论清营化瘀颗粒治疗急性血栓性浅静脉炎的疗效满意,其机制可能为通过调节"炎症-凝血网络",促进静脉血栓溶解和再通。
Objective To observe the clinical effects of＂Qingying Huayu Granule＂in treating acute superficial thrombophlebitis. Method 80 patients with acute superficial thrombophlebitis were randomly divided into treatment group and control group,40 cases in each group. The treatment group was treated with＂Qingying Huayu Granule＂,while the control group was treated with Tong Sai Mai Tablet,with the course of 30 days for two groups. The clinical effect and the related biochemical index（ WBC,TNF-α,CRP and IL-6） were observed. Results 1The clinical total effective rate of the treatment group and the control group were92. 50% and 80% respectively,and the curative effect of the treatment group was better than that of the control group（ P 0. 05）. 2Compared before and after the treatment,the levels of TNF-α,CRP,and IL-6 were significantly decreased in each group（ P 0. 05）; after treatment,the levels of IL-6,CRP and TNF-αin the treatment group were significantly lower than those in the control group（ P 0. 05）. Conclusion ＂Qingying Huayu Granule ＂was effective on treating superficial thrombophlebitis in acute period,and the possible mechanism is dissolving and reperfusing venous thrombosis by regulating the inflammation coagulation network.
出处
《上海中医药杂志》
2016年第2期52-54,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市卫计委进一步加快中医药事业发展三年行动计划资助项目(ZY3-JSFC-2-1013)
关键词
血栓性浅静脉炎
青蛇毒
急性期
清营化瘀颗粒
血热壅滞
凝血-炎症网络
superficial thrombophlebitis
green-blue snake toxin sore
acute phase
＂Qingying Huayu Granule＂
blood stasis
coagulation and inflammation network
