摘要
肿瘤细胞的形成和转移与基因的表达调控密切相关,阐明单体化合物的作用机制是将其用于肿瘤治疗的重要环节。本文综述了三氧化二砷和青蒿素抗肿瘤的分子机制,其抗肿瘤作用主要包括调节:1细胞周期调控蛋白抑制肿瘤细胞增殖;2细胞凋亡信号转导途径促进肿瘤细胞凋亡;3细胞永生化相关基因减低肿瘤细胞寿命;4血管生成和浸润转移基因阻止肿瘤细胞扩散;5启动子甲基化和蛋白泛素化基因促进抑癌基因表达和泛素化介导的蛋白质降解;6微小RNA抑制肿瘤细胞增殖或诱导凋亡;7DNA合成与损伤修复基因抑制肿瘤细胞DNA合成;8细胞增殖、凋亡和侵袭转移等信号转导通路;9细胞激素受体等蛋白的表达。作者对当前研究过程中存在的问题进行了分析,也对单体化合物治疗肿瘤疾病的前景进行了展望。
The formation and metastasis of tumor cells are closely related to the gene regulation. It is critical to elucidate the molecular mechanism of a compound using in cancer therapy. In this article, we reviewed the anti-cancer molecular mechanism of arsenic trioxide and artemisinin. Its anti-cancer function mainly includes: regulation of 1 cell cycle regulatory proteins to inhibit tumor cell proliferation, 2 cell apoptosis signal transduction pathway to promote apoptosis in tumor cells, 3 immortalization associated genes to reduce the life of tumor cells, 4 angiogenesis/invasion/metastasis gene to block the spread of tumor cells, 5 promoter methylation and protein ubiquitination gene to enhance anti-oncogene expression and ubiquitin- mediated protein degradation, 6 micro RNA to inhibit proliferation or induce apoptosis in tumor cells, 7 DNA synthesis and repair of DNA damage and repair gene to decrease the DNA synthesis of tumor cells, 8 signal transduction pathways of cell proliferation/apoptosis and invasion/metastasis etc., 9 the expression of hormone receptors and so on. We indicated the problems existing in current studies and also prospected the future of using the compound to fight cancer.
出处
《药学学报》
CAS
CSCD
北大核心
2016年第2期208-214,共7页
Acta Pharmaceutica Sinica
基金
国家自然科学基金青年基金资助项目(81302809)
上海市卫生与计划生育委员会科研基金(20154Y0149)
上海交通大学医工交叉基金项目(YG2015MS24)
上海交通大学医学院附属第三人民医院科研基金项目(syzrc2014-001
syz2014-005)
上海交通大学医学院附属第三人民医院肿瘤学科建设项目
关键词
三氧化二砷
青蒿素
抗肿瘤
分子机制
arsenic trioxide
artemisinin
anti-cancer
molecular mechanism