摘要
目的:观察注射用丹参多酚酸盐治疗冠心病心绞痛合并2型糖尿病的疗效。方法:将120例冠心病心绞痛合并2型糖尿病患者随机分为治疗组、对照组两组,每组各60例,两组患者均给予常规药物,如抗血小板、调脂、ACEI、β受体阻滞剂、降糖药物等。治疗组注射用丹参多酚酸盐(上海绿谷制药有限公司生产)200 mg加入5%葡萄糖注射液或0.9%氯化钠注射液250 m L/d静滴。两组连续治疗10 d为1个疗程,治疗1个疗程。评价两组的心绞痛疗效和心电图,观察两组治疗前后的硝酸甘油减停数和血糖指标改变情况。结果:1心绞痛疗效:治疗组的总有效率为85.0%,显著高于对照组的60.0%(P<0.05)。2心电图评价:治疗组缺血改善率为70.0%,对照组为60.0%,差异有统计学意义(P<0.05)。3硝酸甘油停减数:治疗后两组的硝酸甘油停减数较治疗前均显著改善(P<0.05)。4糖尿病指标:治疗后两组糖尿病指标较治疗前均有明显改善,与治疗前比较差异有统计学意义(P<0.05)。结论:注射用丹参多酚酸盐明显改善冠心病心绞痛合并2型糖尿病患者的临床症状、心电图及糖尿病相关临床指标,减少硝酸甘油用量,且安全性良好,是治疗冠心病心绞痛合并2型糖尿病安全而有效的药物。
Objective：To investigate the effect with salvianolate injection on patients with angina pectoris in coronary heart diseases and type two diabetes. Methods：Total of 120 patients with angina pectoris in coronary heart diseases and type two diabetes were enrolled and randomly divided into the treatment group and the control group. Each group of 60 were treated with conventional drugs,as antiplatelet drugs,lipid drugs,ACEI,beta-adrenoceptor antagonist,antidiabetes drug etc. The treatment group was treated with salvianolate injection,200 mg/d mixed with 0.9% sodium chloride solution 250 m L/d,ivgtt,qd for 10 days. It was evaluated the effect of two groups of angina pectoris and ECG and observed treatment of nitroglycerin stopped reduction in the before and after and glycemic index change situation in two groups. Results：1AP effect：The treatment group total effective rate was 85.0%,significantly higher than that of control group 60.0%（P0.05）.2ECG evaluation：The treatment group was 70.0% in improvement of Ischemia period,the control group was 60.0%,and the difference was statistically significant（P0.05）.3nitroglycerin stopped reduction,Nitroglycerin stopped reduction compared with before treatment in two groups after treatment were significantly improved（P0.05）.4Diabetes indicators：Diabetes indicators in two groups after treatment were significantly improved,compared with the indicators before,the difference was statistically significant（P0.05）. Conclusion：Salvianolate injection can have an obvious improvement on ECG and diabetes indicators of the patients with angina pectoris in coronary heart diseases and type two diabetes. It also can reduce the dosage of nitroglycerin and provide a good safe treatment that is a kind of good effective drug which treats on angina pectoris in coronary heart diseases and type two diabetes.
出处
《辽宁中医药大学学报》
CAS
2016年第2期122-124,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
辽宁省科技厅项目(2012225018)
关键词
冠心病
心绞痛
2型糖尿病
注射用丹参多芬酸盐
coronary heart diseases
angina pectoris
type two diabetes
salvianolate injection
