摘要
动脉粥样硬化是严重危害人类健康的重大疾病。新近的研究表明,前蛋白转化酶枯草溶菌素9作为降解低密度脂蛋白受体的重要分子,影响前蛋白转化酶枯草溶菌素9-低密度脂蛋白受体途径导致低密度脂蛋白代谢异常,与动脉粥样硬化形成的关系密切。现就前蛋白转化酶枯草溶菌素9影响动脉粥样硬化研究进展做一综述。
Atherosclerosis is a serious disease that is harmful to human health. Proprotein convertase subtilisin/kexin type 9 （ PCSK9 ）, a newly recognized protein, which plays a key role in cholesterol homeostasis by enhancing the degradation of hepatic low-density lipoprotein receptor and causing marked increases in low-density lipoprotein cholesterol concentration and atherosclerosis. This review pro- vides important links between PCSK9, low-density lipoprotein receptor and the mechanisms of atherosclerosis.
出处
《心血管病学进展》
CAS
2016年第1期50-53,共4页
Advances in Cardiovascular Diseases
基金
重庆市科委自然科学基金计划资助项目(cstc2012jj A10045)
重庆市渝中区科委科技计划项目(20130129)
