摘要
高胆固醇血症为心血管疾病的重要危险因素,其与心血管疾病的并发症及病死率密切相关。高胆固醇血症与诸多基因的多态性相关。以下综述与高胆固醇血症密切相关的低密度脂蛋白受体(LDLR)、载脂蛋白(apo)和前蛋白转化酶枯草溶菌素9(PCSK9)基因及其多态性与高胆固醇血症发生、发展及临床症状间的关系。
Hypercholesterolemia is an important risk factor of cardiovascular disease, which is related to complications and mortality of cardiovascular disease. A lot of researches show that some genes polymorphism was related to hypercholesterolemia. This paper introduces the hypercholesterolemia, including LDLR （low-density lipoprotein）, apo （apolipoprotein） and PCSK9 （proprotein convertase subtilisin kexin type 9）, etc, and summed up the relationship between the genes polymorphism and hypercholesterolemia.
出处
《医学研究生学报》
CAS
2009年第5期548-551,共4页
Journal of Medical Postgraduates
基金
南京市科技发展计划项目基金资助(批准号:200603004)
关键词
高胆固醇血症
基因多态性
低密度脂蛋白受体
载脂蛋白
PCSK9
Hypercholesterolemia
Gene polymorphism
Low density lipoprotein receptor
Apolipoprotein
Proprotein convertase subtilisin kexin type 9
