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CT图像引导下三维腔内后装治疗宫颈癌的临床疗效 被引量:11

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摘要 目的探讨老年宫颈癌患者三维适形放疗联合三维后装治疗后胃肠道毒性反应及其相关影响因素。方法 56例局部晚期老年宫颈癌患者,进行盆腔外照射50 Gy/25 f后,进行CT图像引导下192Ir三维腔内后装治疗,观察胃肠道毒性反应率及相关影响因素、总生存率(OS)、无病生存(DFS)、盆腔复发、远处转移情况。结果中位随访时间22.4个月,胃肠道毒性反应16例(28.6%)(1级14例,2级1例,3级1例)。在严格控制剂量体积限制的前提下,多因素分析显示胃肠道毒性反应与FIGO分期及是否同步化疗密切相关,而与年龄、瘤体大小、淋巴结转移及放疗持续时间未显示明显的关联性。56例患者2年OS 87.5%(95%CI 61.7%~96.8%),无病生存率(DFS)78.6(95%CI 49.7%~89.8%)局部复发率(RF)7.1%(95%CI 0%~12.6%),远处转移率(DF)14.3%(95%CI 5.7%~23.4%)。结论联合三维后装患者胃肠道毒性反应明显减少,尤其是3级反应,FIGO分期及是否同步化疗与胃肠道毒性反应的发生率密切相关,具有显著统计学差别。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2016年第4期870-871,共2页 Chinese Journal of Gerontology
基金 吉林省科技发展计划项目(No.20150204076SF)
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参考文献5

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