摘要
目的：评价人绒毛膜促性腺激素（human chorionic gonadotropin,h CG）日血清孕酮水平与B型超声（B超）下直径≥14 mm的卵泡数比值（progesterone-to-follicle index,PFI）与体外受精-胚胎移植（in vitro fertilization-embryo transfer,IVF-ET）治疗结局的关系。方法：回顾性分析2013年1月—2013年8月于我院行IVF助孕的384个IVF周期的患者资料,根据妊娠结局的不同分组比较组间h CG日孕酮、PFI等资料,再根据h CG日PFI将研究对象分为3组：PFI〈0.05为A组,0.05-0.10为B组,PFI≥0.10为C组,比较组间的一般资料和临床结局。结果：妊娠组h CG日孕酮水平以及PFI均低于对照组,差异有统计学意义（P〈0.05）;A、B组h CG日雌二醇（E_2）水平均高于C组,差异有统计学意义（P〈0.05）;A组h CG日孕酮水平低于B、C组,且B组低于C组,差异均有统计学意义（P〈0.05）;A组的种植率高于C组,差异有统计学意义（P〈0.05）。结论：h CG日高PFI可能预测不良IVF-ET种植结局。
Objective：To investigate the pregnancy outcomes of in vitro fertilization-embryo transfer（IVFET） related to the progesterone-to-follicle index（PFI）, which is the ratio of serum progesterone level to the number of follicle with diameter ≥14 mm on the day of h CG administration in IVF cycles. Methods：A retrospective analysis was performed on the data of 384 IVF cycles between January 2013 and August 2013. The level of progesterone and PFI were compared between pregnancy patients and non-pregnancy patients. 384 cycles were divided into three groups according to PFI, group A with PFI0.05, group B with PFI 0.05-0.10, and group C with PFI≥0.10. The basic information and pregnancy outcome were analyzed. Results：The level of progesterone and PFI in the pregnant group were significantly lower than those in the non-pregnant group（P〈0.05）. The levels of estradiol in the group A and the group B were significantly higher than that in the group C（P〈0.05）.The level of progesterone in the group A was significantly lower than those in the group B and the group C, while the level of progesterone in the group B was significantly lower than that in the group C（P〈0.05）. The implantation rate in the group A was significantly higher than that in the group C（P〈0.05）. Conclusions：The higher PFI on the h CG day may predict adverse implantation outcome of IVF-ET.
出处
《国际生殖健康／计划生育杂志》
CAS
2016年第1期13-16,共4页
Journal of International Reproductive Health/Family Planning
基金
国家自然科学基金(81370767
81401276)
关键词
孕酮
卵泡
种植结局
Progesterone
Ovarian follicle
Implantation outcome
