摘要
目的分析非酒精性脂肪肝(NAFLD)患者和健康对照组的一般特征和临床指标,探讨其相关危险因素,为防治提供依据。方法根据B超检查诊断,体检患者分为正常对照组(4 086例)和NAFLD病例组(1 699例),比较两组人群的一般特征和各临床指标。结果各年龄段NAFLD的患病率有明显的性别差异。NAFLD病例组身体质量指数(BMI)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FBG)、尿酸(UA)、收缩压(SBP)、舒张压(DBP)均显著升高,而高密度脂蛋白胆固醇(HDL-C)显著降低(P<0.05)。logistic回归分析显示BMI(OR为4.30)、TG(OR为1.94)、FBG(OR为1.86)、舒张压(OR为1.02)、HDL-C(OR为0.61)、LDL-C(OR为1.27)、ALT(OR为1.02)、AST/ALT(OR为0.40)进入方程,是独立危险因素(P<0.05)。与NAFLD关系较为密切的指标是BMI、TG、FBG和LDL-C,可较好地预测NAFLD。结论 NAFLD患者具有肥胖、糖脂代谢紊乱(高FBG、高TG、高LDL-C、低HDL-C)、高血压、高尿酸的特征,且肝酶升高。BMI、FBG、TG、HDL-C、LDL-C、DBP、ALT是发生NAFLD的独立危险因素。另外,女性雌激素水平的降低可能是NAFLD的致病因素。
Objective To study general characteristics and clinical indicators of subjects in nonalcoholic fatty liver disease（NAFLD）group and health control group;to analyze related risk factors and provide basis for disease prevention and control.Methods Based on type B ultrasonic diagnosis,subjects taking physical examination were divided into health control group（4 086subjects）and NAFLD group（1 699subjects）,general characteristics and various clinical indicators were compared and difference was analyzed between 2groups.Results Statistical difference was observed for NAFLD incidences between different genders in all age groups.Compared with control group,subjects in NAFLD group had significantly higher level of body mass index（BMI）,alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,total cholesterol（TC）,triglyceride（TG）,fasting blood glucose（FBG）,uric acid（UA）,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,and significantly lower level of high density lipoprotein cholesterol（HDL-C）（all P0.05）.logistic regression analysis showed that BMI（OR=4.30）,TG（OR=1.94）,FBG（OR=1.86）、DBP（OR=1.02）,HDL-C（OR=0.61）,LDL-C（OR=1.27）,ALT（OR=1.02）,AST/ALT（OR=0.40）were independent risk factors of NAFLD（all P0.05）.BMI,TG,FBG and LDL-C were indicators closely related with NAFLD,which could be used to predict onset of NAFLD.Conclusion NAFLD patients had characteristics of obesity,glycol-lipids abnormalty（high level of FBG,TC,TG,LDL-C and low level of HDL-C）,hypertension,hypeluricemia and elevated indicators of liver enzymes.BMI,FBG,TG,HDL-C,LDL-C,DBP and ALT were independent risk factors of NAFLD.In addition,the decreased level of estrogen might be cause of NAFLD in females.
出处
《江苏预防医学》
CAS
2016年第1期21-25,共5页
Jiangsu Journal of Preventive Medicine
基金
国家自然科学基金面上项目(81372980
8100185)
关键词
非酒精性脂肪肝
危险因素
体质指数
糖脂代谢
代谢综合征
Nonalcoholic fatty liver disease
Risk factor
Body mass index
Glyco-lipids metablism
Metabolic syndrome
