摘要
目的观察甲状腺癌患者血清脂肪细胞因子（Chemerin）的水平变化，并探讨其与甲状腺癌临床病理特征及预后的相关性。方法采用酶联免疫吸附试验（ELISA）测定55例甲状腺癌患者、50例甲状腺良性肿瘤患者7L20例健康对照患者的血清Chemerin水平。分析其表达水平与临床病理特征和生存预后的相关性。结果血清Chemerin水平甲状腺癌组（2302．64±235．32）ng／L，良性甲状腺肿瘤组（1643．82±204．65）ng／L．健康对照组（1013．17±144．52）ng／L，三组比较差异有统计学意义（F=14．156，P〈0．05）。血清Chemerin在甲状腺癌中的表达与TNM分期、淋巴结转移有关（P〈0．05）；术后复发患者血清Chemerin水平（2562．73±251．35）ng／L明显高于未复发患者（2101．32±244．25）ng／L。（P=0．0013）。Chemerin低表达组患者生存时间明显高于高表达组（P=0．0001）；多因素分析显示，Chemerin水平和TNM分期是影响甲状腺癌生存的独立预后因素。结论甲状腺癌患者外周血Chemerin水平显著升高，与术后复发和生存预后密切相关，可能成为指导治疗和判断复发和预后的一个参考指标。
Objective To investigate the change of serum Chemerin levels and its relation with clinicopathological characteristics in papillary thyroid carcinoma patients. Methods The expression of Chemerin was determined by ELISA in 55 papillsry carcinoma cases, 50 benign thyroid tumor cases and 20 normal persons. The association of serum Chemerin level with the clinicopathological charactersistics, overall survival and prognosis were analyzed. Result s The level of Chemerin was the highest in papillary thyroid carcinoma cases I （ 2302.64 ± 235.32 ） ng/L ] , higher in benign throid tumors [ （ 1643.82 ± 204.65 ） ng/L ] , and low in normal persons [ （ 1013.17 ± 144.52） ng/L ] , showing significant difference among three groups （ F= 14.156, P〈0.05 ） . The serum level of Chemerin in papillary thyroid carcinoma were positively correlated with TNM stage and lymph node metastasis （ P〈0.05 ） .A significantly higher Chemerin level was found in patients with recurrence during the follow-up [ （ 2562.73 ± 251.35 ） ng/L ] compared with those without recurrence [ （ 2101.32 ± 244.25 ） ng/L, （ P=0.0013 ） ] . A higher serum Chemerin level was significantly associated with a poorer overall survival （ P=0.0001 ） .Multivariate analysis revealed that Chemerin level and TNM stage were independent predictors for overall survival. Conclusion The expression of Chemerin in patients with papillary thyroid carcinoma is increased. Chemerin may be used as a reference indicator to judge direction therapy and to predict the reccurrence and prognosis.
出处
《浙江临床医学》
2016年第3期440-442,共3页
Zhejiang Clinical Medical Journal
关键词
脂肪细胞因子
甲状腺癌
预后
Chemerin Papillary thyroid carcinoma Prognosis
