摘要
目的观察瑞舒伐他汀钙治疗对慢性心力衰竭患者心功能、血脂和血清N-端脑钠肽前体（NT-pro BNP）水平的影响。方法将2014年4月-2015年4月我院收治的56例慢性心力衰竭患者按就诊顺序随机分为对照组和治疗组。对照组患者给予基础治疗,治疗组患者在对照组的基础上加服瑞舒伐他汀钙。两组疗程均为3个月。比较治疗前后两组患者的心功能NYHA分级、左室射血分数（LVEF）、血脂指标（TC、TG、HDL-C及LDL-C）和NT-pro BNP水平,并考察观察期间的心血管事件发生率（卒中、心梗、死亡）及不良反应。结果治疗后,两组患者的心功能NYHA分级均较其治疗前有改善（P〈0.01）,但两组间比较,差异无统计学意义（P〉0.05）。治疗后,两组患者的LVEF均较其治疗前有改善（P〈0.01）,且治疗组的LVEF、NT-pro BNP水平均优于对照组,两组比较,差异均有统计学意义（P〈0.05）;治疗组血脂LDL-C水平较其治疗前有改善（P〈0.01）,与对照组比较,差异亦有统计学意义（P〈0.05）。治疗过程中,对照组有3例患者因再次心力衰竭而入院。结论瑞舒伐他汀钙治疗慢性心力衰竭可以改善患者的心功能,并可降低其NT-pro BNP水平和LDL-C等指标。
Objective To investigate the treatment effects of rosuvastatin calcium therapy on patients with chronic heart failure（the level of heart function,blood lipids and Brain natriuretic peptide）. Methods From Apr 2014 to Apr 2015,a total of 56 cases of hospitalized patients with chronic heart failure were randomly by 1：1treated basis of the treatment（control group）,or adding rosuvastatin calcium on the base treatment（treatment group）.After treatment of 3 months,2 groups were compared with heart function improve（NYHA grade,LVEF）,blood lipid indexes（TC,TG,HDL-C and LDL-C）and the level of NT-pro BNP. Also to observe the incidence of cardiovascular events during the period（including stroke,myocardial infarction,death）. Results After treatment,the 2 groups were significantly improved with NYHA classification of cardiac function than their treatment before（P〈0.01）,but there was no significant difference between the 2 groups（P〈0.05）.After treatment,2 groups of LVEF were better than their treatment before（P〈0.01）,also the differences of levels of NT-pro BNP LVEF in 2 groups was statistically significant（P〈0.05）. After treatment,the LDL-C levels in observation group have improved significantly than treatment before（P〈0.01）,and there were statistically significant differences in the 2 groups also（P〈0.05）. During the observation period,3 patients hospitalized for heart failure again in the control group. Conclusion Treatment of rosuvastatin calcium in the chronic heart failure can significantly improve patient＇s cardiac function,decrease the level of NT-pro BNP and LDL-C.
出处
《中国卫生标准管理》
2016年第1期82-84,共3页
China Health Standard Management
关键词
瑞舒伐他汀钙
慢性心力衰竭
血清N-端脑钠肽前体
低密度脂蛋白
Rosuvastatin calcium
Chronic heart failure
Brain natriuretic peptide
Low density lipoprotein-cholesterol
