摘要
目的评价芪苈强心胶囊治疗高龄慢性心力衰竭患者的临床疗效及安全性,为临床合理用药提供依据。方法入选≥80岁老年慢性心力衰竭患者60例,随机分为对照组和治疗组,每组30例。2组均给予利尿剂、琥珀酸美托洛尔缓释片(倍他乐克)或地高辛等常规西药治疗.治疗组另加服芪苈强心胶囊4粒,每天3次。治疗8周后对比观察临床疗效、血清脑钠肽(BNP)和心脏彩色Doppler超声心动图检测心功能指标(CI、LVEF、SV、CO),并观察不良反应。结果疗程结束后治疗组临床总有效率为93.33%(28/30),高于对照组73.34%(22/30),差异有统计学意义(P<0.05)。BNP水平2组治疗后均较治疗前降低(P<0.05),治疗组较对照组BNP水平下降更明显(P<0.05)。HR、SV、CO、CI、LVEF值2组治疗后较治疗前有所改善(P<0.05),但2组间比较差异无统计学意义(P>0.05)。2组均未发生严重不良反应。结论芪苈强心胶囊辅治慢性心力衰竭疗效明确,安全性好,可作为高龄慢性心力衰竭患者的药物治疗选择之一。
Objective To evaluate the clinical efficacy of Qiliqiangxin capsule and safety on very elderly patients with chronic heart failure , and provide the basis for rational drug use .Methods 60 patients who were ≥80 year old with chronic heart failure were enrolled and randomly divided into control group and the treatment group , 30 cases in each group .2 groups were given diuretics , metoprolol succinate extended release tablets （ metoprolol ） or digoxin and other conventional western medicine, treatment group plus Qiliqiangxin capsule, 3 times a day.After 8 weeks of treatment, observed the clinical efficacy of serum brain natriuretic peptide （ BNP） and cardiac color Doppler echocardiography cardiac function index （ CI, LVEF, SV, CO） , and observed adverse reactions .Results In treatment group after treatment , the total effective rate was 93.33%（28/30）, higher than control group of 73.34%（22/30）, the difference was statistically significant （ P 〈0.05）. BNP levels in the two groups after treatment were reduced than before treatment （ P 〈0.05）, the treatment group compared with the control group, BNP levels decreased more significantly （ P 〈0.05）.After treatment, HR, SV, CO, CI, LVEF val-ues of the two groups were improved than before treatment （ P 〈0.05）, but no difference between the two groups was statisti-cally significant （ P ＆gt;0.05）.Both two groups found no serious adverse events .Conclusion Qiliqiangxin capsule clearly assisted treatment of chronic heart failure efficacy , safety, and can be used in very elderly patients with chronic heart failure .
出处
《疑难病杂志》
CAS
2014年第4期339-341,共3页
Chinese Journal of Difficult and Complicated Cases
关键词
芪苈强心胶囊
高龄老年
心力衰竭
慢性
临床研究
Qiliqiangxin capsule
Very elderly
Heart failure,chronic
Clinical research
