摘要
目的 分析治疗后梅毒患者（包括隐性梅毒,血清固定型,已治愈患者）行体外受精-胚胎移植（IVF-ET）和卵胞浆内单精子显微注射（ICSI）的结局,为其知情选择提供帮助。方法 回顾性分析2009年~2014年在我院行IVF/ICSI治疗的不孕症夫妻,将其分为非梅毒患者、单独男方梅毒患者、单独女方梅毒患者、双方梅毒患者4组,比较其正常受精率、优质胚胎率、临床妊娠率及流产率。结果 双方梅毒患者,正常受精率为54.5%（P〈0.01）明显低于其它组,结果有统计学差异（P均〈0.05）。然而这4组的优质胚胎率、临床妊娠率及流产率均无统计学差异（P均〉0.05）。结论 治疗后梅毒患者行IVF/ICSI时,虽然双方梅毒患者的正常受精率偏低,但受精后形成优质胚胎、临床妊娠率及流产率与其它组均无显著性差异。治疗后梅毒患者,不影响IVF/ICSI的妊娠结局。故医护人员在告知治疗后梅毒患者行IVF/ICSI时可不必过分担心与非梅毒患者的正常受精率、优质胚胎率、临床妊娠率及流产率差异,减轻病人的心理压力。
Objective： To analyze the outcomes of in vitro fertilization-embryo transfer （IVF-ET） and intracytoplasmic sperm injection （ICSI） treatment in patients with syphilis （including latent syphilis, sero-fixation and cured patients） , in order to improving service quality of informed choice. Methods： The data of infertile couples in treatment with IVF//CSI in our hospital from 2009 to 2014 were retrospectively investigated and divided into 4 groups： non syphilis group, men with syphilis only, women with syphilis only and both with syphilis group. The normal fertilization rate, good quality embryo rate, clinical pregnancy rate and abortion rate were compared. Results： The normal fertilization rate of patients in both with syphilis group was 54.5% （P 〈0.01） , significantly lower than other groups （P〈0.05） . While the good quality embryo rate, clinical pregnancy rate and abortion rate showed no statistical differences （P〉0.05） . Conclusions： When treated with IVF/ICSI after treatment of syphilis, although the normal fertilization rate of patients in both with syphilis group was lower than other groups, its good quality embryo rate, clinical pregnancy rate and abortion rate after fertilization were no significant differences. The pregnancy outcomes of patients who were treated with IVF/ICSI after treatment of syphilis were unaffected. So when telling the patients after treatment of syphilis about the IVF/ICSI, medical staff should not fuss about the differences of normal fertilization rate, good quality embryo rate, clinical pregnancy rate and abortion rate with the patients without syphilis, so as to reduce the patients＇ psychological pressure.
出处
《中国优生与遗传杂志》
2016年第2期118-119,125,共3页
Chinese Journal of Birth Health & Heredity
关键词
梅毒
体外受精-胚胎移植
ICSI
正常受精率
Syphilis： In vitro fertilization-embryo transfer
Intracytoplasmic sperm injection, Normal fertilization rate
