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枸橼酸咖啡因联合高流量加温湿化经鼻导管正压通气治疗早产儿呼吸暂停临床观察 被引量:8

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摘要 目的 探讨枸橼酸咖啡因联合高流量加温湿化经鼻导管正压通气(HHFNC)治疗早产儿呼吸暂停的临床疗效。方法 将我科新生儿重症监护病房诊断为早产儿呼吸暂停的新生儿65例,随机分为对照组31例及观察组34例。对照组常规采用氨茶碱静脉给药治疗;观察组应用枸橼酸咖啡因联合高流量加温湿化经鼻导管正压通气治疗;观察指标:(1)72小时内发生呼吸暂停次数;需要有创通气例数;呼吸暂停消失时间;总用氧时间。结果 72小时内发生呼吸暂停次数(x±s):对照组(11.2±2.7),观察组(6.1±1.5),t=9.52,P〈0.001;需要有创通气例数:对照组13例,观察组6例,χ^2=4.62,P〈0.05;呼吸暂停消失时间(x±s,h):对照组(143.3±30.1),观察组(96.4±21.3),t=7.30,P〈0.001;总用氧时间(x±s,h):对照组(155.3±32.12),观察组(110.7±24.3),t=6.35,P〈0.001。结论 枸橼酸咖啡因联合高流量加温湿化经鼻导管正压通气治疗早产儿呼吸暂停疗效明显优于常规应用氨茶碱,副作用小、安全,值得在临床推广应用。
作者 杨一民
出处 《齐齐哈尔医学院学报》 2015年第36期5540-5541,共2页 Journal of Qiqihar Medical University
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