摘要
背景:相关研究已经显示,冠心病和骨质疏松存在共同的病理生理机制,动脉粥样硬化和骨质疏松有明显的相关性。目的:分析骨质疏松症和冠心病患者冠脉病变严重程度的相关性。方法:回顾性分析首次行冠脉造影并明确诊断为冠心病的322例患者资料,将其分为骨质疏松组和非骨质疏松组患者,采用多元线性回归模型分析骨质疏松和反映冠脉病变严重程度的Gensini积分间的相关性。结果与结论:骨质疏松组比非骨质疏松组患者具有较少的冠脉单支病变(P<0.001),更多的冠脉多支病变(P<0.001)和更高的Gensini积分(P<0.001)。在校正可能的影响因素后,多元线性回归显示,骨质疏松是Gensini积分的危险因素(P<0.001)。相关性分析显示,骨密度和Gensini积分呈负相关关系(r=-0.36,P=0.004)。结果表明,骨质疏松和冠心病冠脉病变严重程度密切相关。
BACKGROUND： Studies have shown that coronary heart disease and osteoporosis have the same pathophysiology mechaism, and atherosclerosis is evidently correlated with osteoporosis. OBJECTIVE： To study the relationship between the severity of coronary lesions and osteoporosis in patients with coronary heart disease. METHODS： Totally 322 in-hospital patients diagnosed as having coronary artery disease by coronary angiography were retrospectively selected and divided into osteoporosis group and non-osteoporosis group. Multiple linear regression model was used to analyze the correlation between osteoporosis and Gensini score indicating the severity of coronary lesion. RESULTS AND CONCLUSION： Patients in the osteoporosis group had fewer coronary single branch lesions（P 〈 0.001）, more coronary multivessel lesions（P 〈 0.001） and higher Gensini score（P 〈 0.001） compared with those in the non-osteoporosis group. Multivariate linear regression analysis showed osteoporosis was a risk factor of Gensini score（P 〈 0.001） after adjustment for possible factors. Correlation analysis showed that bone mineral density and Gensini score were negatively correlated（r=-0.36, P=0.004）. These findings indicate that osteoporosis is closely related to the severity of coronary artery disease.
出处
《中国组织工程研究》
CAS
北大核心
2015年第51期8213-8217,共5页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金(81260410)~~
