摘要
目的:探讨左甲状腺素钠联合钙剂在不同服用时间对老年甲状腺功能减退症患者甲状腺激素的影响。方法:选取2011年4月—2014年3月间收治的150例老年甲状腺功能减退症患者为研究对象,按随机数字表法分为对照1组、对照2组和观察组,对照1组50例患者早晨空腹同时服用左甲状腺素钠与钙剂;对照2组50例患者早晨空腹服用左甲状腺素钠,睡前服用钙剂;观察组50例患者晚餐后4 h以上、睡前服用左甲状腺素钠,2餐间服用钙剂;观察各组患者的促甲状腺激素(TSH)水平和临床疗效。结果:对照1组患者TSH较前有所上升,症状未改善;对照2组和观察组患者的TSH均较治疗前有所改善,且观察组改善程度较对照2组更明显,差异有统计学意义(P<0.05)。3组患者均未见明显不良反应。结论:老年甲状腺功能减退症患者晚餐后4 h以上、睡前服用左甲状腺素钠,并与其他食物、药物隔开服用,临床效果更佳。
OBJECTIVE：To probe into the effects of taking levothyroxine sodium and calcium at different time on thethyroid hormone of elderly patients with hypothyroidismin.METHODS：150 elderly hypothyroidism patients admitted into the hospital from Apr.2011 to Mar.2014 were selected as the research objects,who were divided into the control group one,control group two and the observation group.50 cases in the control group one were given levothyroxine sodium and calcium on an empty stomach.50 cases in the control two received levothyroxine sodium on an empty stomach,and calcium was given in bedtime.50 cases in observation group were given levothyroxine sodium at bedtime,after dinner of four hours,and took calcium between meals.The levels of thyroid stimulating hormone（ TSH） and clinical efficacy of three group of patients were observed.RESULTS：TSH in control group one had increased 10 times,and the symptoms did not improve.Compared with before treatment,TSH in control group two and observation group were improved after treatment,and the observation group had been improved more significant than the control group two,with statistical difference（ P〈0.05）.There were no obvious adverse reactions in three groups.CONCLUSIONS：The elderly patients with hypothyroidism should take levothyroxine sodium in bedtime,after dinner of four hours,and other foods and medications should be separated from the drugs,by which the drugs could achieve a better clinical efficacy.
出处
《中国医院用药评价与分析》
2015年第11期1444-1446,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
