摘要
目的:基于中医证候疗效评价安肠汤对腹泻型肠易激综合征(IBS-D)肝郁脾虚证的临床疗效,探索疏肝在IBS-D肝郁脾虚证治疗中的重要地位,为IBS-D中医治疗提供一定的循证医学依据。方法:将120例辨证为肝郁脾虚证的IBS-D患者随机分为4组:A组(安肠汤组)、B组(痛泻要方组)、C组(柴胡疏肝散组)、D组(匹维溴铵组),分别予相应药物治疗,疗程均为4周。于治疗前后记录患者的症状、体征,并进行中医证候评分。结果:A、B、D组治疗后中医证候积分均较治疗前显著降低(P<0.01),且A组优于B、C组(P<0.01),但A组与D组比较,差异无统计学意义(P>0.05)。综合疗效A组明显优于B、C组(P<0.01),但A组与D组比较,差异无统计学意义(P>0.05)。结论:安肠汤对腹泻型肠易激综合征肝郁脾虚证有较好的临床疗效,表明疏肝在IBS-D的治疗中具有重要作用。
Objective： To investigate the clinical efficacy of Anchang Decoction in the treatment of the liver depression and spleen deficiency syndrome of diarrhea- predominant irritable bowel syndrome（ IBS- D） based on the evaluation of therapeutic effect on traditional Chinese medicine（ TCM） syndrome,as well as the role of liver- soothing treatment in the liver depression and spleen deficiency syndrome of IBS- D,and to provide a basis of evidence-based medicine for TCM treatment of IBS- D. Methods： A total of 120 IBS- D patients with the syndrome of liver depression and spleen deficiency were randomized into four groups： group A（ Anchang Decoction group）,group B（ Tongxieyaofang group）,group C（ Chaihu Shugan Powder group）,and group D（ pinaverium bromide group）. Each group was given the corresponding drug therapy,and the course of the treatment was 4 weeks. The patients＇ symptoms and signs were recorded and TCM syndrome scores were obtained before and after treatment. Results： The groups A,B,and D had significant reductions in TCM syndrome scores after treatment（ all P 0. 01）,and group A had a significantly greater reduction than groups B and C（ both P 0. 01）,but there was no significant difference between group A and group D（ P 0. 05）. Group A had a significantly better overall outcome than groups B and C（ both P 0. 01）,but there was no significant difference between group A and group D（ P 0. 05）. Conclusion： Anchang Decoction has good clinical efficacy in the treatment of the liver depression and spleen deficiency syndrome of IBS- D,suggesting that liver- soothing treatment plays an important role in the treatment of IBS- D.
出处
《湖南中医杂志》
2015年第12期11-13,共3页
Hunan Journal of Traditional Chinese Medicine
基金
广西壮族自治区自然基金资助项目(编号:2012GXNSFAA053099)
广西壮族自治区科学研究与技术开发计划基金资助项目(编号:桂科攻1298003-7-2)
关键词
肠易激综合征
腹泻型
肝郁脾虚证
中医药疗法
安肠汤
diarrhea-predominant irritable bowel syndrome
liver depression and spleen deficiency
traditional Chinese medicine treatment
Anchang Decoction
