摘要
社会老龄化关联的神经退行性疾病已成为不容忽视的医学和社会问题,药物治疗至今无法达到令人满意的治疗效果。干细胞移植替代疗法可单独或结合药物治疗,为神经退行性疾病的治疗提供了新的途径。本文就目前干细胞移植在神经退行性疾病的治疗中取得的研究进展进行总结,包括阿尔茨海默病、帕金森病、亨廷顿舞蹈病和肌萎缩性侧索硬化症等,探讨干细胞移植在治疗神经退行性疾病方面的有效性、安全性和可行性,以及存在的困难和问题。同时也对干细胞移植治疗神经退行性疾病在未来发展中可能遇到的挑战进行了展望,希望能为其将来在临床上进一步应用提供一定的参考依据。
Degeneration of neurons contributed to the pathological process of neurodegenerative diseases. Neurodegeneration was the most common cause of dementia in the elderly with a worldwide prevalence estimated to quadruple over the next 50 years,specific treatments that could slow or stop neurodegeneration were not available yet. Regenerative medicine offered new avenues for developing effective therapies for neurodegeneration. Success of cell replacement therapy in this field may largely depend on readily available and unlimited supply of desired functional cell types. Replacement therapy of cell transplantation could treat with drugs alone or in combination with the treatment of neurodegenerative diseases. In this paper,we summarized the research progress of cell transplantation in the treatment of neurodegenerative diseases,including Alzheimer＇ s disease,Parkinson＇ s disease,Huntington＇s disease and amyotrophic lateral sclerosis. In order to explore the effectiveness,safety and feasibility of cell transplantation in the treatment of neurodegenerative diseases, as well as the difficulties and problems were also disscussed. Our work also laid a foundation for the development of neural degenerative diseases during clinical applications.
出处
《中华移植杂志（电子版）》
CAS
2015年第4期188-193,共6页
Chinese Journal of Transplantation(Electronic Edition)
基金
国家自然科学基金青年基金项目(81503048)
浙江省自然科学基金青年基金项目(LQ13H020001)
浙江省中西医结合学会临床药学科研基金振德专项(2013LYZD002)
关键词
干细胞
神经退行性疾病
细胞移植
再生医学
Stem cells
Neurodegenerative disease
Cell transplantation
Regenerative medicine
