摘要
目的探讨血清C反应蛋白(CRP)/高分子量脂联素(HMWA)比值与代谢综合征(MS)的相关性,分析CRP/HMWA比值作为一种新的生物学标志物在预测MS过程中与单独使用CRP、HMWA相比是否具有优势。方法共纳入研究对象170例,根据2009年国际多学会联合声明(JIS)的MS诊断标准分为MS组(n=94)和非代谢综合征(non-MS)组(n=76);所有研究对象均行口服葡萄糖耐量试验(OGTT)及胰岛素释放试验。采用ELISA法测定血清HMWA浓度,采用化学发光法测定血清CRP浓度。结果 MS组血清CRP/HMWA比值水平高于non-MS组(P<0.01)。简单相关分析显示,血清CRP/HMWA水平与体质指数(BMI)、腰围(WC)、腰臀比(WHR)、收缩压(SBP)、空腹血糖(FPG)、OGTT 2 h血糖(2h PG)、空腹胰岛素(FIns)、OGTT 2 h胰岛素(2h Ins)、糖化血红蛋白(Hb A1c)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、稳态模型胰岛素抵抗指数(HOMA-IR)、CRP呈正相关(P<0.05或P<0.01),与高密度脂蛋白胆固醇(HDL-C)、胰岛β细胞功能(HOMA-β)、HMWA呈负相关(P<0.01)。Logistic回归显示,血清CRP/HMWA升高是MS的危险因素(P<0.05)。高CRP低HMWA组MS检出率高于低CRP高HMWA组(P<0.01)。血清CRP/HMWA预测MS的ROC曲线下面积高于CRP及HMWA(P<0.05)。结论与血清CRP、HMWA相比,用血清CRP/HMWA预测MS更有价值。
Objective To investigate the relationship of ratio of serum C-reactive protein（CRP） to high-molecular-weight adiponectin （CRP/HMWA ratio） levels with metabolic syndrome （MS） and evaluate whether CRP/HMWA ratio is more useful than CRP or HMWA value alone for prediction of MS. Methods A total of 170 Chinese subjects were divided into MS group（ n = 94） and non-MS group （n = 76） respectively based on the criteria of 2009 Joint Interim Statement. Oral glucose tolerance test （OGTF） and insulin relea- sing test were performed for all subjects. Fasting serum HMWA level was determined by ELISA. Serum CRP concentrations were meas- ured by chemiluminescence method. Results Serum CRP/HMWA ratio of MS patients was significantly higher than that of non-MS subjects（ P 〈 0.01 ）. Serum CRP/HMWA ratio positively correlated with body mass index（BMI） , waist circumference（WC） , waist to hip ratio（ WHR）, systolic blood pressure（ SBP）, fasting blood glucose（ FPG）, OGTY 2-hour postload glucose（2hPG）, fasting insulin （ Fins ）, OGTF 2-hour insulin （ 2 bins ）, glycosylated hemoglobin A1 C （ HbA 1 c ）, triacylglycerol （ TG）, total cholesterol（ TC ）, low den- sity lipoprotein cholesterol（LDL-C） , homeostasis model insulin resistance index（HOMA-IR） and CRP（ P 〈 0.05 or P 〈 0.01 ） , but negatively correlated with high density lipoprotein cholesterol（ HDL-C）, HOMA-[3 and HMWA（ P 〈 0.01 ）. Logistic regression analysis revealed that increased CRP/HMWA ratio was associated with elevated odds of MS（ P 〈 0.05 ）. The diagnosis rate of MS in the high CRP-low HMWA group was higher than that in low CRP-high HMWA group （ P 〈 0.01 ）. The AUC of CRP/HMWA ratio in receiver operating characteristic curve（ROC） analysis for MS was significantly greater than that of CRP or HMWA alone（ P 〈0.05 ）. Conclu- sion Serum CRP/HMWA ratio might be superior marker for predicting MS compared with CRP or HMWA alone.
出处
《临床检验杂志》
CAS
CSCD
2015年第11期808-812,共5页
Chinese Journal of Clinical Laboratory Science
基金
国家自然科学基金面上项目(81570721
81370965)
江苏省自然科学基金(BK20151331
BK2009208)
江苏省卫生厅国际交流支撑计划及面上科技项目(H201247)
"六大人才高峰"第十二批高层次人才项目(2015-WSN-006)
镇江市科技支撑-社会发展重点项目(SH2015028)
镇江市科技支撑-社会发展面上项目(SH2015042
SH2012027
SH2013035)
镇江市医学重点人才项目(2014)
关键词
高分子量脂联素
C反应蛋白
代谢综合征
胰岛素抵抗
high-molecular-weight adiponectin
C-reactive protein
metabolic syndrome
insulin resistance
